Mangiferin (CAS 4773-96-0)
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Mangiferin, a natural polyphenolic compound found in the leaves and bark of mango trees (Mangifera indica), possesses remarkable properties such as antioxidant, antimicrobial, anti-inflammatory, and anti-cancer effects. Investigations have delved into its impact on cancer, inflammation, and oxidative stress, as well as its influence on cell viability, signaling pathways, and gene expression. Mangiferin exhibits diverse biochemical and physiological effects by modulating enzyme activity, including cyclooxygenase-2, and impeding the production of pro-inflammatory cytokines. Through multiple mechanisms, mangiferin is believed to act as an antioxidant, neutralizing free radicals and inhibiting lipid peroxidation. It also influences cell signaling pathways involved in inflammation and cancer. Moreover, mangiferin has shown the ability to induce apoptosis in cancer cells and inhibit the growth of bacteria and fungi.
Mangiferin (CAS 4773-96-0) References
- Mangiferin and its traversal into the brain. | Zajac, D., et al. 2013. Adv Exp Med Biol. 756: 105-11. PMID: 22836625
- Mangiferin positively regulates osteoblast differentiation and suppresses osteoclast differentiation. | Sekiguchi, Y., et al. 2017. Mol Med Rep. 16: 1328-1332. PMID: 28627701
- Mangiferin Improved Palmitate-Induced-Insulin Resistance by Promoting Free Fatty Acid Metabolism in HepG2 and C2C12 Cells via PPARα: Mangiferin Improved Insulin Resistance. | Zhang, Q., et al. 2019. J Diabetes Res. 2019: 2052675. PMID: 30809553
- Mangiferin glycethosomes as a new potential adjuvant for the treatment of psoriasis. | Pleguezuelos-Villa, M., et al. 2020. Int J Pharm. 573: 118844. PMID: 31751638
- Mangiferin promotes macrophage cholesterol efflux and protects against atherosclerosis by augmenting the expression of ABCA1 and ABCG1. | Ren, K., et al. 2019. Aging (Albany NY). 11: 10992-11009. PMID: 31790366
- Mangiferin exert cardioprotective and anti-apoptotic effects in heart failure induced rats. | Jiang, T., et al. 2020. Life Sci. 249: 117476. PMID: 32119962
- PINK1-PRKN mitophagy suppression by mangiferin promotes a brown-fat-phenotype via PKA-p38 MAPK signalling in murine C3H10T1/2 mesenchymal stem cells. | Rahman, MS. and Kim, YS. 2020. Metabolism. 107: 154228. PMID: 32289346
- Mangiferin activates Nrf2 to attenuate cardiac fibrosis via redistributing glutaminolysis-derived glutamate. | Song, J., et al. 2020. Pharmacol Res. 157: 104845. PMID: 32353588
- Mangiferin prevents myocardial infarction-induced apoptosis and heart failure in mice by activating the Sirt1/FoxO3a pathway. | Chen, L., et al. 2021. J Cell Mol Med. 25: 2944-2955. PMID: 33523605
- Mangiferin inhibited neuroinflammation through regulating microglial polarization and suppressing NF-κB, NLRP3 pathway. | Lei, LY., et al. 2021. Chin J Nat Med. 19: 112-119. PMID: 33641782
- Mangiferin attenuates IL-1β-induced chondrocytes apoptosis. | Zhu, P., et al. 2021. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 46: 25-31. PMID: 33678633
- The protective effect of mangiferin on osteoarthritis: An in vitro and in vivo study. | Wang, Y., et al. 2022. Physiol Res. 71: 135-145. PMID: 35043648
- Explaining the interaction of mangiferin with MMP-9 and NF-ƙβ: a computational study. | Gálvez-Rodríguez, A., et al. 2022. J Mol Model. 28: 266. PMID: 35987945
- Mangiferin alleviates hyperglycemia-induced endothelial impairment via Nrf2 signaling pathway. | Jayasuriya, R. and Ramkumar, KM. 2022. Eur J Pharmacol. 936: 175359. PMID: 36332683
- Mangiferin relieves CCl4-induced liver fibrosis in mice. | Zhang, L., et al. 2023. Sci Rep. 13: 4172. PMID: 36914687
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Mangiferin, 10 mg | sc-491041 | 10 mg | $140.00 |