ETHE1 Inhibitors
Chemical inhibitors of ETHE1 can interfere with its activity by disrupting the mitochondrial environment where ETHE1 functions. Malonate, as a competitive inhibitor of succinate dehydrogenase, creates a blockade in the tricarboxylic acid (TCA) cycle, leading to a potential buildup of intermediates that could affect the redox state within the mitochondria. This altered state can diminish the functionality of mitochondrial proteins, including ETHE1. Similarly, the action of Oligomycin, by inhibiting ATP synthase, collapses the proton gradient essential for ATP production, which can negatively influence the metabolic processes associated with ETHE1. Antimycin A and Stigmatellin target complex III of the mitochondrial electron transport chain, while Carboxin and Thenoyltrifluoroacetone (TTFA) target complex II, and Rotenone targets complex I. By inhibiting these complexes, these chemicals cause a ripple effect, leading to a decrease in the electron transport chain's efficiency, which is closely tied to the proper functioning of ETHE1.
Furthermore, Sodium azide and Potassium cyanide, both inhibitors of cytochrome c oxidase, can drastically reduce mitochondrial respiration, creating an unfavorable environment for ETHE1's enzymatic activity. Auranofin disrupts cellular redox homeostasis by inhibiting thioredoxin reductase, which can influence the redox-sensitive processes that ETHE1 is part of. Salicylhydroxamic acid (SHAM) inhibits alternative oxidases, which can lead to reduced efficiency of mitochondrial oxidative phosphorylation, indirectly affecting ETHE1 function. Lastly, Atovaquone selectively disrupts mitochondrial electron transport at cytochrome bc1, creating a milieu that is not conducive for ETHE1 activity due to the potential alteration of mitochondrial metabolism.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Oligomycin | 1404-19-9 | sc-203342 sc-203342C | 10 mg 1 g | $146.00 $12250.00 | 18 | |
Oligomycin is an inhibitor of ATP synthase in mitochondrial membranes. It disrupts the proton gradient, which indirectly can inhibit ETHE1 by altering mitochondrial metabolism and potentially affecting ETHE1-related processes. | ||||||
Antimycin A | 1397-94-0 | sc-202467 sc-202467A sc-202467B sc-202467C | 5 mg 10 mg 1 g 3 g | $54.00 $62.00 $1642.00 $4600.00 | 51 | |
Antimycin A inhibits mitochondrial complex III, a component of the electron transport chain. This inhibition can decrease mitochondrial function, which in turn can inhibit ETHE1's function due to its mitochondrial localization. | ||||||
Carboxine | 5234-68-4 | sc-234286 | 250 mg | $21.00 | 1 | |
Carboxin inhibits mitochondrial complex II. By disrupting the electron transport chain, it can indirectly inhibit ETHE1 by affecting mitochondrial respiration and the overall metabolic environment where ETHE1 is active. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $254.00 | 41 | |
Rotenone is an inhibitor of mitochondrial complex I. By impeding electron flow, rotenone can indirectly inhibit ETHE1 by compromising mitochondrial respiratory capacity, which is essential for ETHE1's function. | ||||||
2-Thenoyltrifluoroacetone | 326-91-0 | sc-251801 | 5 g | $36.00 | 1 | |
This compound, also known as TTFA, inhibits mitochondrial complex II. By interfering with mitochondrial respiration, TTFA can indirectly inhibit ETHE1 activity by disrupting the mitochondrial environment. | ||||||
Sodium azide | 26628-22-8 | sc-208393 sc-208393B sc-208393C sc-208393D sc-208393A | 25 g 250 g 1 kg 2.5 kg 100 g | $42.00 $152.00 $385.00 $845.00 $88.00 | 8 | |
Sodium azide inhibits cytochrome c oxidase in the mitochondrial electron transport chain. The resulting mitochondrial dysfunction can indirectly inhibit ETHE1 by impeding proper mitochondrial metabolism. | ||||||
Auranofin | 34031-32-8 | sc-202476 sc-202476A sc-202476B | 25 mg 100 mg 2 g | $150.00 $210.00 $1899.00 | 39 | |
Auranofin inhibits thioredoxin reductase, an enzyme involved in antioxidant defense. Through its action, auranofin can indirectly inhibit ETHE1 by altering the redox state within mitochondria, where ETHE1 operates. | ||||||
Salicylhydroxamic acid | 89-73-6 | sc-236849 | 5 g | $20.00 | ||
SHAM is an inhibitor of alternative oxidases and can disrupt mitochondrial function. By doing so, it can indirectly inhibit ETHE1 by affecting the mitochondrial environment and the metabolic processes essential for ETHE1 activity. | ||||||
Atovaquone | 95233-18-4 | sc-217675 | 10 mg | $265.00 | 2 | |
Atovaquone selectively inhibits mitochondrial electron transport at cytochrome bc1 (complex III). By disrupting this pathway, atovaquone can indirectly inhibit ETHE1 through modulation of mitochondrial function and metabolism. | ||||||