Eso-1 Activators
N-acetyltransferase eso1 Activators are compounds that enhance the functional activity of N-acetyltransferase eso1. Nicotinamide mononucleotide (NMN) and Resveratrol enhance the functional activity of N-acetyltransferase eso1 through their roles in increasing NAD+ levels and activating SIRT1 respectively. Both NMN and Resveratrol influence the acetylation status of proteins within the cell, which can have downstream effects on the activity of N-acetyltransferase eso1. Acetyl-Coenzyme A is a direct substrate for the enzyme's acetyltransferase activity, thus its availability is crucial for N-acetyltransferase eso1 function. Substances that can increase cellular acetyl-CoA levels, such as S-Adenosylmethionine, Coenzyme Q10, Alpha-lipoic acid, and metabolic intermediates, can indirectly enhance the activity of N-acetyltransferase eso1 by ensuring an ample supply of acetyl groups for enzyme function.
Inhibitors of other acetyltransferases, such as Anacardic acid, Curcumin, Garcinol, EGCG, and Quercetin, can lead to an increased acetyl-CoA pool within the cell. By inhibiting competing acetyltransferase pathways, these compounds can make more acetyl-CoA available for N-acetyltransferase eso1, which in turn can enhance its activity. Moreover, compounds like Sulforaphane activate transcription factors such as Nrf2, whichleads to the upregulation of genes that help maintain the cellular redox state. A balanced redox state can indirectly influence the activity of N-acetyltransferase eso1 by preserving the enzyme's structure and function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
β-Nicotinamide mononucleotide | 1094-61-7 | sc-212376 sc-212376A sc-212376B sc-212376C sc-212376D | 25 mg 100 mg 1 g 2 g 5 g | $110.00 $150.00 $220.00 $300.00 $600.00 | 4 | |
NMN is a precursor to NAD+, which is a substrate for sirtuin deacetylases that indirectly activate N-acetyltransferase eso1 by promoting the acetylation of proteins involved in DNA damage response. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates SIRT1, a sirtuin deacetylase, which can lead to changes in the acetylation status of proteins that are substrates for N-acetyltransferase eso1, enhancing its functional activity. | ||||||
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $184.00 $668.00 | 2 | |
S-Adenosylmethionine serves as a methyl donor in numerous methylation reactions and can enhance the methylation status of proteins that interact with N-acetyltransferase eso1, leading to its functional activation. | ||||||
Acetyl coenzyme A trisodium salt | 102029-73-2 | sc-210745 sc-210745A sc-210745B | 1 mg 5 mg 1 g | $47.00 $92.00 $5826.00 | 3 | |
Acetyl-Coenzyme A is a direct donor of acetyl groups and is essential for the acetyltransferase activity of N-acetyltransferase eso1, thereby enhancing its functional activity. | ||||||
Anacardic Acid | 16611-84-0 | sc-202463 sc-202463A | 5 mg 25 mg | $102.00 $204.00 | 13 | |
Anacardic acid inhibits histone acetyltransferase (HAT) enzymes, which could result in the increased availability of acetyl-CoA for N-acetyltransferase eso1, enhancing its activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is known to inhibit histone acetyltransferases, which may lead to an increased pool of acetyl-CoA for N-acetyltransferase eso1, indirectly enhancing its activity. | ||||||
Garcinol | 78824-30-3 | sc-200891 sc-200891A | 10 mg 50 mg | $124.00 $502.00 | 13 | |
Garcinol is an inhibitor of p300/CBP histone acetyltransferase, potentially increasing the availability of acetyl-CoA for N-acetyltransferase eso1 and enhancing its enzymatic activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG has been shown to inhibit several acetyltransferases, which could indirectly enhance the activity of N-acetyltransferase eso1 by increasing acetyl-CoA substrate availability. | ||||||
Coenzyme Q10 | 303-98-0 | sc-205262 sc-205262A | 1 g 5 g | $71.00 $184.00 | 1 | |
Coenzyme Q10 is involved in the mitochondrial electron transport chain and can influence cellular energy status, which in turn can enhance the activity of N-acetyltransferase eso1 by ensuring an adequate supply of acetyl-CoA. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane activates Nrf2, a transcription factor that influences the expression of antioxidant proteins, which can enhance the activity of N-acetyltransferase eso1 by maintaining cellular redox homeostasis. | ||||||