ER beta Inhibitors
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PHTPP | 805239-56-9 | sc-204191 sc-204191A sc-204191B sc-204191C | 10 mg 50 mg 100 mg 20 mg | $189.00 $797.00 $1224.00 $357.00 | 25 | |
High-affinity ERβ antagonist, inhibits ERβ-regulated processes | ||||||
Raloxifene hydrochloride | 82640-04-8 | sc-204230 | 50 mg | $70.00 | 4 | |
Raloxifene hydrochloride functions as a selective modulator of estrogen receptor beta, characterized by its ability to induce specific allosteric changes in the receptor's conformation. Its unique molecular structure facilitates targeted hydrogen bonding and hydrophobic interactions, enhancing its binding affinity. This compound engages in distinct signaling pathways, influencing cellular responses and gene regulation. The kinetics of Raloxifene hydrochloride suggest a nuanced interaction profile, allowing for differential modulation of receptor activity. | ||||||
ICI 182,780 | 129453-61-8 | sc-203435 sc-203435A | 1 mg 10 mg | $81.00 $183.00 | 34 | |
Competitive antagonist, binds to ERβ preventing receptor activation | ||||||
Coumestrol | 479-13-0 | sc-205638 sc-205638A | 10 mg 25 mg | $203.00 $315.00 | 2 | |
Coumestrol acts as a selective estrogen receptor beta agonist, exhibiting unique binding dynamics that promote receptor dimerization and transcriptional activity. Its polycyclic structure allows for specific π-π stacking interactions with aromatic residues, enhancing its affinity for the receptor. Coumestrol's distinct mechanism involves modulation of gene expression through alternative signaling cascades, influencing cellular processes. The compound's stability and reactivity are influenced by its hydroxyl groups, which participate in critical hydrogen bonding networks. | ||||||
(R,R)-THC | 138090-06-9 | sc-204224 sc-204224A | 5 mg 10 mg | $362.00 $617.00 | 1 | |
(R,R)-THC functions as a selective agonist for estrogen receptor beta, characterized by its unique stereochemistry that enhances receptor selectivity. Its molecular conformation facilitates specific hydrophobic interactions with the receptor's binding pocket, promoting effective signal transduction. The compound's ability to induce conformational changes in the receptor leads to distinct downstream effects on gene regulation. Additionally, its interactions with cellular membranes may influence its bioavailability and receptor accessibility. | ||||||
Cyclofenil | 2624-43-3 | sc-255038 sc-255038A | 10 mg 50 mg | $102.00 $428.00 | ||
Cyclofenil acts as a selective modulator of estrogen receptor beta, exhibiting unique binding dynamics that enhance its affinity for the receptor. Its structural features allow for specific hydrogen bonding and hydrophobic interactions, which stabilize the receptor-ligand complex. This modulation can lead to altered receptor conformation, influencing downstream signaling pathways. Furthermore, its lipophilic nature may affect membrane permeability, impacting cellular uptake and distribution. | ||||||
Raloxifene | 84449-90-1 | sc-476458 | 1 g | $802.00 | 3 | |
Selective estrogen receptor modulator, inhibits ERβ activity | ||||||
DPN | 1428-67-7 | sc-203431 sc-203431A | 10 mg 50 mg | $100.00 $423.00 | 4 | |
Highly selective ERβ agonist, activates ERβ-mediated signaling | ||||||
LY500307 | 533884-09-2 | sc-364530 sc-364530A sc-364530B sc-364530C | 5 mg 25 mg 100 mg 200 mg | $600.00 $1600.00 $6000.00 $11223.00 | ||
Synthetic ERβ-selective agonist, activates ERβ transcriptional activity | ||||||
WAY 200070 | 440122-66-7 | sc-301977 sc-301977A | 10 mg 50 mg | $83.00 $435.00 | ||
Potent and selective ERβ agonist, activates ERβ signaling | ||||||