Molecular structure of WAY 200070, CAS Number: 440122-66-7
WAY 200070 (CAS 440122-66-7)
Application:
WAY 200070 is a selective ERβ agonist
CAS Number:
440122-66-7
Purity:
≥98%
Molecular Weight:
306.11
Molecular Formula:
C13H8BrNO3
Supplemental Information:
This is as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
WAY 200070 is a selective ERβ receptor agonist that displays 68-fold selectivity over ERα (EC50 values are 2 and 155 nM for ERβ and ERα respectively). Has been shown to display antianxiolytic and antidepressive effects in vivo.
WAY 200070 (CAS 440122-66-7) References
- Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. | Malamas, MS., et al. 2004. J Med Chem. 47: 5021-40. PMID: 15456246
- Preclinical characterization of selective estrogen receptor beta agonists: new insights into their therapeutic potential. | Harris, HA. 2006. Ernst Schering Found Symp Proc. 149-61. PMID: 17824176
- Differential effects of estrogen receptor alpha and beta specific agonists on social learning of food preferences in female mice. | Clipperton, AE., et al. 2008. Neuropsychopharmacology. 33: 2362-75. PMID: 18004284
- Activation of estrogen receptor-beta regulates hippocampal synaptic plasticity and improves memory. | Liu, F., et al. 2008. Nat Neurosci. 11: 334-43. PMID: 18297067
- WAY-200070, a selective agonist of estrogen receptor beta as a potential novel anxiolytic/antidepressant agent. | Hughes, ZA., et al. 2008. Neuropharmacology. 54: 1136-42. PMID: 18423777
- Estrogen receptor beta is a novel therapeutic target for photoaging. | Chang, KC., et al. 2010. Mol Pharmacol. 77: 744-50. PMID: 20110405
- Agonistic behavior in males and females: effects of an estrogen receptor beta agonist in gonadectomized and gonadally intact mice. | Clipperton Allen, AE., et al. 2010. Psychoneuroendocrinology. 35: 1008-22. PMID: 20129736
- Modulation of responses to stress by estradiol benzoate and selective estrogen receptor agonists. | Serova, LI., et al. 2010. J Endocrinol. 205: 253-62. PMID: 20348154
- Estrogen receptor ß activity modulates synaptic signaling and structure. | Srivastava, DP., et al. 2010. J Neurosci. 30: 13454-60. PMID: 20926671
- Effects of a combined treatment with tamoxifen and estrogen receptor β agonists on human breast cancer cell lines. | Lattrich, C., et al. 2014. Arch Gynecol Obstet. 289: 163-71. PMID: 23907354
- The dietary ingredient, genistein, stimulates cathelicidin antimicrobial peptide expression through a novel S1P-dependent mechanism. | Park, K., et al. 2014. J Nutr Biochem. 25: 734-40. PMID: 24768661
- Estrogen receptor 1 (ESR1; ERα), not ESR2 (ERβ), modulates estrogen-induced sex reversal in the American alligator, a species with temperature-dependent sex determination. | Kohno, S., et al. 2015. Endocrinology. 156: 1887-99. PMID: 25714813
- Effects of lorazepam and WAY-200070 in larval zebrafish light/dark choice test. | Chen, F., et al. 2015. Neuropharmacology. 95: 226-33. PMID: 25842247
- In ovo treatment with an estrogen receptor alpha selective agonist causes precocious development of the female reproductive tract of the American alligator (Alligator mississippiensis). | Doheny, BM., et al. 2016. Gen Comp Endocrinol. 238: 96-104. PMID: 26994582
Inhibitor of:
ER beta.Activator of:
ER beta.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
WAY 200070, 10 mg | sc-301977 | 10 mg | $83.00 | |||
WAY 200070, 50 mg | sc-301977A | 50 mg | $435.00 |