Raloxifene hydrochloride is a selective estrogen receptor modulator (SERM), binding to ERα and ERβ. Tissue-dependently blocks or activates estrogen-induced transcription. Exhibits estrogen agonist behavior in bone but acts as an anti-estrogen in breast and uterine tissue. Raloxifene hydrochloride exhibits inhibitory effects of progesterone receptor induction by estrogen in D12 rat hypothalamic cells. Raloxifene hydrochloride is a substrate of Estrogen Receptor.
Fitzpatrick et al (1999) Effect of estrogen agonists and antagonists on induction of progesterone receptor in a rat hypothalamic cell line. Endocrinology 140 3928. Bryant (2001) Mechanism of action and preclinical profile of raloxifene, a selective estrogen receptor modulator. Rev.Endocr.Metab.Disord. 2 129. Hibner et al (2004) Effects of raloxifene hydrochloride on endometrial cancer cells in vitro. Gynecologic Oncol. 93 642.
Soluble in DMSO (50 mM), methanol, and ethanol (<1 mg/ml at 25° C). Insoluble in water.
can u please explain me about mechanism of this inhibitors that in which manner thhis inhibitors act on estrogen
Asked by: Anam riaz
Thank you for your inquiry and your interest in this product. For further details regarding the inhibitory mechanism of Raloxifene hydrochloride (CAS 82640-04-8) please refer to the product citations and references provided on this site. Please contact Technical Service by phone, (800)-457-3801 option 2, email <[email protected]>, or by live chat directly on our website, www.scbt.com if you have any further questions.
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Manni A; et alManni A; et al. (PubMed ID: 26339626) Raloxifene hydrochloride, antiestrogen and proven to decrease the frequency of estrogen receptor positive tumors. -SCBT Publication Review
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