(R,R)-THC CAS: 138090-06-9
MF: C22H24O2
MW: 320.42
A selective agonist at ERα and antagonist at ERβ.

(R,R)-THC (CAS 138090-06-9)

(R,R)-THC | CAS 138090-06-9 is rated 4.0 out of 5 by 1.
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Alternate Names: (R,R)-cis-Diethyltetrahydro-2,8-chrysenediol; (R,R)-5,11-Diethyl-5,6,11,12-tetrahydro-2,8-chrysenediol
Application: (R,R)-THC is a selective agonist at ERα and antagonist at ERβ
CAS Number: 138090-06-9
Purity: ≥98%
Molecular Weight: 320.42
Molecular Formula: C22H24O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

(R,R)-THC is a non-steroidal, potent, and selective estrogen receptor (ER) ligand; agonist at ERα (Ki = 9.0 nM) and antagonist at ERβ receptor (Ki = 3.6 nM).


References

Sun et al (1999) Novel ligands that function as selective estrogens or antiestrogens for estrogen receptor-a or estrogen receptor-b. Endocrinology 140 800. Kraichely et al (2000) Conformational changes and coactivator recruitment by novel ligands for estrogen receptor-a and estrogen receptor-b: correlations with biological character and distinct differences among SRC coactivator family members. Endocrinology 141 3534.

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), and ethanol (100 mM).
Storage :
Store at -20° C
Melting Point :
199.78° C (Predicted)
Boiling Point :
518.96° C at 760 mmHg (Predicted)
Density :
1.22 g/cm3 (Predicted)
Refractive Index :
n20D 1.65 (Predicted)
IC50 :
Plasmodium falciparum: IC50 = 3.98 µM
Ki Data :
ER beta: Ki= 3.6 nM; ER alpha: Ki= 9.0 nM
pK Values :
pKa: 10.27 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
446849
MDL Number :
MFCD04039999
SMILES :
CC[[email protected]@H]1CC2=C(C=CC(=C2)O)C3=C1C4=C(C[[email protected]]3CC)C=C(C=C4)O

Download SDS (MSDS)

Certificate of Analysis

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(R,R)-THC (CAS 138090-06-9)  Product Citations

See how others have used (R,R)-THC (CAS 138090-06-9). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 23688559  Yu, DD. et al. 2013. Bioorg. Med. Chem. 21: 4266-78.

Citations 1 to 1 of 1 total
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Rated 4 out of 5 by from The chemical is working well in our experiments The chemical is working well in our experiments.
Date published: 2015-10-01
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