(R,R)-THC is a non-steroidal, potent, and selective estrogen receptor (ER) ligand; agonist at ERα (Ki = 9.0 nM) and antagonist at ERβ receptor (Ki = 3.6 nM).
Sun et al (1999) Novel ligands that function as selective estrogens or antiestrogens for estrogen receptor-a or estrogen receptor-b. Endocrinology 140 800. Kraichely et al (2000) Conformational changes and coactivator recruitment by novel ligands for estrogen receptor-a and estrogen receptor-b: correlations with biological character and distinct differences among SRC coactivator family members. Endocrinology 141 3534.
Soluble in DMSO (100 mM), and ethanol (100 mM).
Store at -20° C
199.78° C (Predicted)
518.96° C at 760 mmHg (Predicted)
1.22 g/cm3 (Predicted)
n20D 1.65 (Predicted)
Plasmodium falciparum: IC50 = 3.98 µM
ER beta: Ki= 3.6 nM; ER alpha: Ki= 9.0 nM
pKa: 10.27 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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