Molecular structure of Cyclofenil, CAS Number: 2624-43-3
Cyclofenil (CAS 2624-43-3)
Alternate Names:
4,4′-(Cyclohexylidenemethylene)bisphenol 1,1′-diacetate
Application:
Cyclofenil is a selective estrogen receptor modulator
CAS Number:
2624-43-3
Purity:
≥99%
Molecular Weight:
364.43
Molecular Formula:
C23H24O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A selective estrogen receptor antagonist.
Cyclofenil (CAS 2624-43-3) References
- The inhibitory effects of flavonoids and antiestrogens on the Glut1 glucose transporter in human erythrocytes. | Martin, HJ., et al. 2003. Chem Biol Interact. 146: 225-35. PMID: 14642735
- Fluorine-substituted cyclofenil derivatives as estrogen receptor ligands: synthesis and structure-affinity relationship study of potential positron emission tomography agents for imaging estrogen receptors in breast cancer. | Seo, JW., et al. 2006. J Med Chem. 49: 2496-511. PMID: 16610793
- Effects of cyclofenil diphenol, an agent which disrupts Golgi structure, on proteoglycan synthesis in chondrocytes. | Mason, RM. and Lancaster, CA. 1992. Biochem J. 281 (Pt 2): 525-31. PMID: 1736900
- Fluorimetric determination of cyclofenil using photochemical derivatization. | Pacheco, WF., et al. 2008. Talanta. 74: 1442-9. PMID: 18371802
- Synthesis and identification of hydroxylated metabolites of the anti-estrogenic agent cyclofenil. | Gärtner, P., et al. 2008. J Mass Spectrom. 43: 958-64. PMID: 18576435
- Nonclassical SNAPFL analogue as a Cy5 resonance energy transfer partner. | Kim, SH., et al. 2008. Org Lett. 10: 4931-4. PMID: 18841988
- Functional significance of nuclear estrogen receptor subtypes in the liver of goldfish. | Nelson, ER. and Habibi, HR. 2010. Endocrinology. 151: 1668-76. PMID: 20194729
- Characterization of the pharmacophore properties of novel selective estrogen receptor downregulators (SERDs). | Kieser, KJ., et al. 2010. J Med Chem. 53: 3320-9. PMID: 20334372
- Stress induced hippocampal mineralocorticoid and estrogen receptor β gene expression and long-term potentiation in male adult rats is sensitive to early-life stress experience. | Wang, H., et al. 2013. Psychoneuroendocrinology. 38: 250-62. PMID: 22776422
- Symmetric 4,4'-(piperidin-4-ylidenemethylene)bisphenol derivatives as novel tunable estrogen receptor (ER) modulators. | Sato, M., et al. 2016. Bioorg Med Chem. 24: 1089-94. PMID: 26822566
- Structure-activity relationship study of estrogen receptor down-regulators with a diphenylmethane skeleton. | Nanjyo, S., et al. 2019. Bioorg Med Chem. 27: 1952-1961. PMID: 30940565
- Estrogen Receptors Alpha and Beta in POA-AHA Region Regulate Asymmetrically Ovulation. | Arrieta-Cruz, I., et al. 2019. Cell Mol Neurobiol. 39: 1139-1149. PMID: 31250245
- Development of bivalent triarylalkene- and cyclofenil-derived dual estrogen receptor antagonists and downregulators. | Knox, A., et al. 2020. Eur J Med Chem. 192: 112191. PMID: 32169784
- Improvement in aqueous solubility of achiral symmetric cyclofenil by modification to a chiral asymmetric analog. | Morimoto, J., et al. 2021. Sci Rep. 11: 12697. PMID: 34135380
- Distinct Roles of Estrogen Receptors in the Regulation of Vitellogenin Expression in Orange-Spotted Grouper (Epinephelus coioides). | Ye, Z., et al. 2022. Int J Mol Sci. 23: PMID: 35955769
Inhibitor of:
ER beta.Substrate of:
Estrogen Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cyclofenil, 10 mg | sc-255038 | 10 mg | $104.00 | |||
Cyclofenil, 50 mg | sc-255038A | 50 mg | $437.00 |