Eps15R Activators
Eps15R activators comprise a specialized group of chemical compounds that are designed to modulate the function of the Eps15 homology (EH) domain-containing protein, Eps15R. Eps15R is a protein that plays a pivotal role in the endocytic pathway, a cellular process responsible for internalizing substances from the cell surface. This protein is involved in the formation of clathrin-coated pits and vesicles, which are cellular structures essential for the internalization of various molecules, including nutrients and receptors. Eps15R is characterized by the presence of multiple protein-interaction domains, including EH domains, coiled-coil regions, and ubiquitin-interacting motifs, which collectively facilitate its role in endocytosis. The protein interacts with a network of other proteins to regulate the assembly and disassembly of clathrin-coated structures, and, consequently, the efficiency of endocytosis.
Activators targeting Eps15R are compounds that enhance the protein's endocytic function by stabilizing its active form or by promoting its interaction with other endocytic proteins. By doing so, these activators can influence the rate and efficiency of clathrin-mediated endocytosis. The chemical structure of these activators is such that they can bind to specific domains within Eps15R, potentially leading to an increase in the recruitment of Eps15R to sites of clathrin-coated pit formation, or augmenting its ability to interact with essential binding partners involved in endocytosis. The modulation of Eps15R activity through these activators can provide insight into the molecular mechanisms governing endocytosis and the role that Eps15R plays in this process. Understanding the impact of Eps15R activators on cellular endocytic pathways can also shed light on the broader aspects of cellular trafficking, membrane dynamics, and the regulation of the cellular surface composition.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid can induce gene expression during cell growth and differentiation processes. It could potentially stimulate Eps15R production if this gene is part of the retinoic acid-responsive gene set. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
As a DNA methyltransferase inhibitor, 5-Azacytidine can increase gene expression by causing DNA demethylation. If the EPS15R gene is hypermethylated, this compound could potentially enhance its expression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A can stimulate gene expression by inhibiting histone deacetylation, which results in a more open chromatin structure. This could potentially increase the transcription of EPS15R. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide might indirectly boost Eps15R expression by triggering cellular DNA damage responses. Such responses often involve upregulation of proteins related to DNA repair and endocytosis, like Eps15R. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 18 | |
Sodium Butyrate could potentially increase EPS15R gene expression. As a histone deacetylase inhibitor, it can enhance gene expression by changing chromatin structure to a more relaxed state, making the DNA more accessible for transcription. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin, by increasing cAMP levels, can stimulate gene expression. If EPS15R is part of the cAMP-responsive gene set, Forskolin might induce increased expression. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone could potentially induce the expression of Eps15R as part of the cellular response to stress. As a glucocorticoid, it often stimulates the upregulation of various genes. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol could potentially enhance the expression of Eps15R as part of cellular metabolism and stress responses. As a polyphenol, it often increases the expression of various genes. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin might stimulate the expression of Eps15R by modulating the activity of several transcription factors. This modulation could lead to a broad upregulation of gene expression. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
DL-Sulforaphane could potentially enhance Eps15R expression as part of its role in activating stress response and detoxification pathways, which often involve gene upregulation. | ||||||