Epilysin Inhibitors
Epilysin inhibitors are a class of chemical compounds designed to specifically target and inhibit the activity of epilysin, also known as matrix metalloproteinase-28 (MMP-28). Epilysin is an enzyme that plays a significant role in the remodeling of the extracellular matrix by degrading various protein components. These inhibitors function by binding to the active site of epilysin, effectively blocking its enzymatic activity. Chemically, epilysin inhibitors often feature functional groups capable of coordinating with the zinc ion present in the active site of MMPs, such as hydroxamic acids, carboxylic acids, or thiols. The presence of these groups allows the inhibitors to chelate the zinc ion, which is essential for the catalytic activity of the enzyme.
The development of epilysin inhibitors involves meticulous structure-based design to achieve high specificity and potency. Researchers utilize techniques like X-ray crystallography and molecular modeling to understand the three-dimensional structure of epilysin and identify key binding sites. By analyzing the unique structural features of epilysin compared to other MMPs, scientists can design inhibitors that selectively bind to epilysin without affecting other metalloproteinases. The inhibitors are optimized through iterative processes to enhance interactions such as hydrogen bonds, hydrophobic contacts, and electrostatic forces between the inhibitor and the enzyme. Additionally, modifications to the chemical structure are made to improve properties like solubility, stability, and bioavailability. These efforts result in epilysin inhibitors that are effective tools for studying the role of MMP-28 in various biological processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Doxycycline-d6 | 564-25-0 unlabeled | sc-218274 | 1 mg | $16500.00 | ||
Doxycycline may downregulate Epilysin by binding to the 30S ribosomal subunit, leading to a decrease in protein synthesis including key transcription factors for MMP-28. | ||||||
Tetracycline | 60-54-8 | sc-205858 sc-205858A sc-205858B sc-205858C sc-205858D | 10 g 25 g 100 g 500 g 1 kg | $63.00 $94.00 $270.00 $417.00 $634.00 | 6 | |
Tetracycline may disrupt the production of Epilysin by hindering the attachment of aminoacyl-tRNA to the mRNA-ribosome complex, which is essential for the synthesis of MMP-28. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA might decrease Epilysin levels by activating protein kinase C, which subsequently alters the phosphorylation state of transcription factors responsible for MMP-28 expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid may suppress Epilysin expression through the retinoic acid receptor, which can bind to the promoter region of the MMP-28 gene and repress its transcription. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone could inhibit Epilysin by activating glucocorticoid receptors, which can bind to glucocorticoid response elements on the MMP-28 gene and suppress its transcription. | ||||||
Alendronate acid | 66376-36-1 | sc-337520 | 5 g | $135.00 | 2 | |
Alendronate acid may reduce the production of Epilysin in osteoblasts by inhibiting farnesyl diphosphate synthase, which in turn could lower the expression of various MMPs, including MMP-28. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin Gallate could inhibit Epilysin by preventing the transcriptional activity of AP-1, a transcription factor involved in the gene expression of MMP-28, by inhibiting its DNA-binding activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin may downregulate Epilysin expression by suppressing the activation of NF-kB, a transcription factor that promotes the expression of various MMPs, including MMP-28. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol could decrease Epilysin levels by inhibiting the activation of STAT3, a transcription factor known to enhance the expression of MMP-28. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 may potently decrease Epilysin expression by inhibiting JNK, which is involved in the signaling pathways that control the transcription of MMP-28. | ||||||