EMILIN-5 Inhibitors
EMILIN-5 inhibitors are a class of chemical compounds that specifically target the EMILIN-5 protein, a member of the elastin microfibril interface-located (EMILIN) protein family. EMILIN proteins are involved in the structure and function of the extracellular matrix (ECM), where they contribute to tissue organization and integrity by interacting with microfibrils and other ECM components. EMILIN-5 is believed to play a role in regulating cell adhesion, migration, and the assembly of extracellular structures, particularly in connective tissues. By targeting EMILIN-5, these inhibitors interfere with its ability to modulate interactions between cells and the ECM, potentially disrupting the structural stability and signaling pathways that depend on proper ECM function.
Inhibition of EMILIN-5 can lead to alterations in the mechanical properties and organization of the ECM, affecting cellular behavior and tissue architecture. EMILIN-5 is involved in maintaining the elasticity and structural integrity of tissues by facilitating the assembly of elastin fibers and microfibrils, which are essential for the resilience and flexibility of connective tissues. Inhibitors of EMILIN-5 may disrupt this process, leading to changes in ECM composition and elasticity. This disruption can have downstream effects on processes like cell migration, tissue repair, and the overall mechanical properties of tissues. By inhibiting EMILIN-5, researchers can study the protein's role in ECM dynamics, gaining insights into how it contributes to tissue homeostasis and the broader organization of extracellular networks. These inhibitors are valuable tools for exploring the molecular mechanisms that govern ECM function and the role of EMILIN-5 in maintaining tissue structure.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin could suppress EMILIN-5 expression by downregulating nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), a transcription factor that can upregulate genes involved in ECM remodeling. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol may reduce EMILIN-5 expression by hindering the activation of sirtuin 1 (SIRT1), leading to decreased transcription of ECM component genes. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is thought to decrease EMILIN-5 synthesis by attenuating the signal transducer and activator of transcription 3 (STAT3) signaling pathway, which is involved in the regulation of various genes encoding ECM proteins. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin Gallate could lead to reduced transcription of EMILIN-5 by inhibiting the extracellular signal-regulated kinase (ERK) pathway, which plays a role in cell proliferation and differentiation. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
DL-Sulforaphane may target EMILIN-5 by restraining the hypoxia-inducible factor 1-alpha (HIF-1α), which is known to contribute to ECM production under hypoxic conditions. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein has the potential to lower EMILIN-5 levels by antagonizing estrogen receptor signaling, which can influence the expression of various ECM proteins. | ||||||
Indole-3-carbinol | 700-06-1 | sc-202662 sc-202662A sc-202662B sc-202662C sc-202662D | 1 g 5 g 100 g 250 g 1 kg | $39.00 $61.00 $146.00 $312.00 $1032.00 | 5 | |
Indole-3-carbinol could lead to a decrease in EMILIN-5 by altering the metabolism of estrogen, thereby potentially disrupting estrogen-responsive elements on genes related to the ECM. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid might specifically inhibit EMILIN-5 by binding to retinoic acid receptors (RARs), which are transcription factors that govern the expression of ECM components. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Cholecalciferol could contribute to a diminished expression of EMILIN-5 through the vitamin D receptor (VDR), which binds to promoter regions of genes involved in ECM regulation. | ||||||
Caffeic Acid | 331-39-5 | sc-200499 sc-200499A | 1 g 5 g | $32.00 $62.00 | 1 | |
Caffeic acid could lead to a decline in EMILIN-5 levels by directly targeting the mitogen-activated protein kinase (MAPK) pathway, which is implicated in the transcriptional control of numerous genes. | ||||||