Elongin A3 Activators
Elongin A3 activators are compounds that influence transcriptional mechanisms and chromatin architecture, thereby modulating the activity of transcription elongation factors. Trichostatin A and Vorinostat relax chromatin by increasing histone acetylation, which can facilitate the progression of RNA polymerase II and its associated factors, including Elongin A3. The altered chromatin state induced by these compounds enhances the transcriptional capacity of genes, which in turn could necessitate and promote the function of elongation factors to accommodate the increased transcriptional demand.
Additionally, compounds like 5-Azacytidine and Mithramycin A, which affect DNA methylation and DNA binding, respectively, alter the transcriptional landscape in such a way that the transcriptional machinery may require additional support from factors like Elongin A3. Modifiers of the epigenetic state such as S-Adenosylmethionine and Anacardic acid indirectly influence the transcriptional machinery by changing the availability of methyl groups for epigenetic marks, potentially affecting transcription elongation. Hormones like β-Estradiol that modulate transcriptional profiles may also impact the need for transcriptional elongation factors. Meanwhile, MG-132 can prevent the degradation of transcription-related factors, potentially leading to an increased presence of Elongin A3 in the nucleus.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
A histone deacetylase inhibitor that can relax chromatin structure, enhancing transcription and potentially increasing the activity of transcriptional elongation factors like Elongin A3. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor that can cause hypomethylation of DNA, leading to an open chromatin state and potentially facilitating the action of transcriptional elongation factors such as Elongin A3. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Another histone deacetylase inhibitor that can promote transcription by expanding the euchromatin region, possibly enhancing Elongin A3 activity. | ||||||
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $180.00 $655.00 | 2 | |
A coenzyme involved in methyl group transfers, which could influence histone and DNA methylation states, possibly affecting transcriptional elongation by Elongin A3. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
By modulating gene expression and differentiation signals, retinoic acid can alter the transcriptional landscape, potentially increasing the requirement for transcriptional elongation factors like Elongin A3. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
A hormone that can modulate gene expression patterns; its presence can alter transcriptional demands and potentially upregulate the function of Elongin A3. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
that binds to DNA and interferes with transcription, potentially requiring greater involvement of elongation factors like Elongin A3 to overcome transcriptional blocks. | ||||||
Anacardic Acid | 16611-84-0 | sc-202463 sc-202463A | 5 mg 25 mg | $100.00 $200.00 | 13 | |
A histone acetyltransferase inhibitor that may influence chromatin structure and thereby affect the function of transcriptional elongation factors including Elongin A3. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
An isoflavone that has been shown to modulate gene expression and possesses potential to alter transcriptional regulation, which could impact the activity of Elongin A3 indirectly. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
A short-chain fatty acid that acts as a histone deacetylase inhibitor, can lead to a more relaxed chromatin structure and thereby potentially increase the activity of transcriptional elongation factors including Elongin A3. | ||||||