eIF2C3 Inhibitors
eIF2C3 inhibitors represent a group of compounds that either directly or indirectly modulate the activity of eIF2C3, a key player in RNA silencing and post-transcriptional gene regulation. These inhibitors offer valuable tools for studying the intricate network of cellular processes in which eIF2C3 is involved. Direct eIF2C3 inhibitors, such as Salubrinal and ISRIB, target specific components of the eIF2α phosphorylation pathway. Salubrinal inhibits the dephosphorylation of eIF2α by targeting the protein phosphatase 1 (PP1) complex. On the other hand, ISRIB blocks eIF2B from binding to phosphorylated eIF2α, promoting translation recovery. These chemicals directly impede eIF2C3's function by altering the phosphorylation status of eIF2α, a critical regulator of translation initiation.
Indirect eIF2C3 inhibitors, like Guanabenz and Guanfacine, influence eIF2C3 through the integrated stress response (ISR). By acting as α2-adrenergic receptor agonists, they activate the PERK pathway, reducing eIF2α phosphorylation and indirectly impacting eIF2C3. Similarly, compounds like Rapamycin and Dactolisib indirectly modulate eIF2C3 by targeting the mTOR pathway, altering protein synthesis and translation processes that eIF2C3 relies on. Additionally, agents like Tunicamycin and Thapsigargin induce endoplasmic reticulum (ER) stress, leading to eIF2α phosphorylation via the PERK pathway. These compounds indirectly influence eIF2C3 activity by altering the cellular response to ER stress. Finally, chemicals such as Pateamine A and Homoharringtonine indirectly impact eIF2C3 by disrupting translation initiation or ribosomal function, crucial processes for eIF2C3's role in RNA-induced silencing complex (RISC). In summary, eIF2C3 inhibitors encompass a diverse group of chemicals that target various pathways and processes, ultimately leading to the modulation of eIF2C3's activity in RNA silencing and post-transcriptional gene regulation. These compounds offer researchers valuable tools to dissect the intricate mechanisms governing gene expression at the post-transcriptional level.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Salubrinal | 405060-95-9 | sc-202332 sc-202332A | 1 mg 5 mg | $34.00 $104.00 | 87 | |
Salubrinal is a selective inhibitor of eIF2α dephosphorylation. It targets the protein phosphatase 1 (PP1) complex and prevents its activity, resulting in increased phosphorylation of eIF2α. This elevated phosphorylation reduces protein synthesis and indirectly inhibits eIF2C3 by modulating the translation initiation process. | ||||||
ISRIB | 1597403-47-8 | sc-488404 | 10 mg | $300.00 | 1 | |
ISRIB acts as a small molecule inhibitor of the integrated stress response (ISR). It works by blocking the binding of eIF2B to phosphorylated eIF2α, thus promoting translation recovery. By regulating the eIF2α-mediated signaling pathway, ISRIB indirectly influences eIF2C3 activity. | ||||||
Guanabenz acetate | 23256-50-0 | sc-203590 sc-203590A sc-203590B sc-203590C sc-203590D | 100 mg 500 mg 1 g 10 g 25 g | $102.00 $468.00 $832.00 $4162.00 $7283.00 | 2 | |
Guanabenz acetate is an α2-adrenergic receptor agonist that can attenuate eIF2α phosphorylation by activating the PERK pathway. By reducing eIF2α phosphorylation, it indirectly modulates eIF2C3 function as a downstream consequence of the integrated stress response. | ||||||
Guanfacine | 29110-47-2 | sc-353618 | 200 mg | $1900.00 | ||
Guanfacine, similar to Guanabenz, is an α2-adrenergic receptor agonist. It can influence the PERK-eIF2α pathway, leading to reduced eIF2α phosphorylation and, consequently, indirect modulation of eIF2C3 activity through the integrated stress response. | ||||||
Farnesyl thiosalicylic acid | 162520-00-5 | sc-205322 sc-205322A | 1 mg 5 mg | $61.00 $82.00 | 15 | |
Farnesyl thiosalicylic acid is a Ras inhibitor that can affect the Ras-ERK pathway. This pathway indirectly connects with eIF2C3 modulation by influencing downstream signaling cascades, ultimately impacting eIF2C3 function through a network of intracellular signaling. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an mTOR inhibitor that regulates protein synthesis. It indirectly modulates eIF2C3 activity by influencing mTOR-dependent signaling pathways. The suppression of mTOR activity results in altered protein translation, affecting eIF2C3's role in RNA silencing. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine is an inhibitor of phosphodiesterases, which can lead to increased levels of cAMP. Elevated cAMP levels activate PKA, leading to eIF2α phosphorylation. Consequently, caffeine indirectly influences eIF2C3 by affecting the cAMP-PKA-eIF2α pathway. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a SERCA inhibitor that induces endoplasmic reticulum (ER) stress. ER stress can activate the PERK-eIF2α pathway, leading to eIF2α phosphorylation. Thapsigargin, therefore, indirectly modulates eIF2C3 activity by altering the ER stress response. | ||||||
BEZ235 | 915019-65-7 | sc-364429 | 50 mg | $211.00 | 8 | |
BEZ235 is a dual PI3K/mTOR inhibitor. It affects the PI3K/AKT/mTOR pathway, which indirectly regulates eIF2C3 by modulating downstream signaling. Changes in this pathway's activity can impact eIF2C3 function through altered translation and cellular processes. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Tunicamycin inhibits N-linked glycosylation and induces ER stress, leading to the activation of the PERK-eIF2α pathway. This, in turn, indirectly influences eIF2C3 activity by affecting translation initiation during ER stress response. | ||||||