EHBP1 Inhibitors
EHBP1 inhibitors, as a chemical class, target diverse pathways and processes closely intertwined with the roles and functions of EHBP1, especially its involvement in endocytic trafficking and actin cytoskeleton dynamics. Key among these inhibitors are agents like Cytochalasin D and Latrunculin A, which modulate actin dynamics either by preventing polymerization or binding to actin monomers. Disruption or alterations in the actin cytoskeleton can significantly influence EHBP1's associated roles, given its close association with actin-mediated processes.
On the endocytic front, molecules like Dynasore act by inhibiting the GTPase activity of dynamin, crucial for vesicle scission during endocytosis. In tandem, PI3K inhibitors such as Wortmannin and LY294002 impede phosphoinositide signaling, a pivotal pathway for actin remodeling and vesicle formation. Other significant contributors like EHT 1864 and ML141 inhibit Rac1 GTPase, a central player in actin polymerization and endocytic activities.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
An agent that binds to actin filaments, preventing their polymerization. EHBP1 is associated with actin cytoskeleton dynamics, so inhibiting actin polymerization can indirectly affect EHBP1's functions related to vesicle trafficking. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Binds actin monomers, sequestering them and preventing them from polymerizing. By hindering actin dynamics, this compound can indirectly modulate EHBP1's function in endocytic processes. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $89.00 | 44 | |
A small molecule that inhibits the GTPase activity of dynamin, which plays a role in endocytosis. EHBP1, being involved in endocytic trafficking, can be indirectly affected when dynamin's activity is suppressed. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
Stabilizes actin filaments and induces actin polymerization. By altering actin dynamics, it can indirectly modulate the functions of EHBP1 linked to the actin cytoskeleton. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Disrupts microtubule polymerization. While EHBP1 is primarily associated with actin dynamics, any disturbance in cellular cytoskeleton components, including microtubules, can have secondary effects on EHBP1's role. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
PI3K inhibitor affecting phosphoinositide signaling. Since phosphoinositide dynamics play a role in actin remodeling and endocytosis, inhibition here can indirectly affect EHBP1's associated functions. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
Another PI3K inhibitor that affects phosphoinositide signaling, potentially influencing EHBP1's role in endocytic trafficking and actin dynamics indirectly. | ||||||
EHT 1864 | 754240-09-0 | sc-361175 sc-361175A | 10 mg 50 mg | $213.00 $889.00 | 12 | |
Rac1 GTPase inhibitor. As Rac1 is involved in actin polymerization and endocytosis, its inhibition can indirectly influence EHBP1's associated activities. | ||||||
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $137.00 $512.00 | 7 | |
Another inhibitor of the Rac1 GTPase, thus by affecting actin cytoskeleton remodeling, EHBP1's function can be indirectly modulated. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $183.00 $313.00 $464.00 $942.00 $1723.00 | 7 | |
Myosin II inhibitor. By suppressing myosin II activity, actin dynamics can be indirectly influenced, potentially impacting EHBP1's associated roles. | ||||||