Egr-1 Activators
Early growth response protein 1 (Egr-1) is a transcription factor encoded by the EGR1 gene in humans. It plays a crucial role in various cellular processes, including proliferation, differentiation, apoptosis, and response to stress signals. Egr-1 is involved in the regulation of a wide array of target genes, making it a key player in controlling cellular responses to environmental cues and stimuli. Its functions are particularly significant in the context of cellular growth and development, as well as in the response to injury and stress. Egr-1 is expressed in many tissues and cell types, indicating its widespread importance in cellular physiology.
The activation of Egr-1 is mediated through several signaling pathways and cellular stimuli. One of the primary mechanisms of activation involves the mitogen-activated protein kinase (MAPK) signaling pathway, where extracellular stimuli such as growth factors, cytokines, and stress signals activate MAPK cascades, leading to the phosphorylation and activation of Egr-1. Additionally, Egr-1 can be activated by calcium signaling pathways, which play crucial roles in cellular responses to various stimuli. Furthermore, Egr-1 activation can be induced by oxidative stress, hypoxia, and other cellular stressors, which trigger specific signaling cascades leading to the activation of Egr-1 transcriptional activity. Importantly, the activation of Egr-1 is tightly regulated, with multiple layers of control ensuring appropriate responses to environmental stimuli while preventing aberrant activation. Overall, the activation of Egr-1 represents a complex interplay of signaling pathways and cellular responses, highlighting its importance as a key regulator of cellular physiology and stress responses.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Thrombin from human plasma | 9002-04-4 | sc-471713 | 100 U | $230.00 | ||
Thrombin activates Egr-1 through the activation of protease-activated receptors (PARs). Thrombin binding to PARs initiates signaling cascades that involve MAPK pathways, leading to Egr-1 activation and subsequent gene expression. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Increases cAMP levels, potentially influencing pathways that activate Egr- | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin directly activates Egr-1 by inhibiting protein synthesis and activating stress-activated protein kinases (SAPKs). SAPKs, including JNK and p38, phosphorylate and activate Egr-1, inducing gene expression. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187, a calcium ionophore, activates Egr-1 through a calcium-dependent mechanism. Increased intracellular calcium levels activate calmodulin-dependent kinase (CaMK), leading to Egr-1 activation and subsequent gene expression. | ||||||
4α-Phorbol 12,13-didecanoate | 27536-56-7 | sc-201210 sc-201210A | 1 mg 5 mg | $184.00 $663.00 | 3 | |
4α-Phorbol 12,13-didecanoate activates Egr-1 by stimulating protein kinase C (PKC), leading to the phosphorylation of Elk-1 and subsequent Egr-1 activation. This chemical acts as an activator of the PKC/Elk-1/Egr-1 signaling pathway. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Activates protein kinase C (PKC), which can lead to the activation of signaling pathways involving Egr- | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $45.00 $56.00 $183.00 | 142 | |
Sodium orthovanadate indirectly activates Egr-1 by inhibiting tyrosine phosphatases. Inhibition of phosphatases results in sustained activation of growth factor receptors and downstream signaling, leading to Egr-1 activation. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000C | 10 µg 100 µg 1 mg | $160.00 $750.00 $3000.00 | 59 | |
Calyculin A, a protein phosphatase inhibitor, activates Egr-1 by inhibiting protein phosphatases. Inhibition of phosphatases leads to sustained phosphorylation of Elk-1 and subsequent Egr-1 activation, inducing gene expression. | ||||||
Allyl disulfide | 2179-57-9 | sc-252359 | 25 g | $78.00 | ||
DADS activates Egr-1 through the p38 MAPK pathway. DADS induces p38 activation, which phosphorylates and activates Egr-1, leading to gene expression. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $94.00 $259.00 | 2 | |
Ionomycin activates Egr-1 through a calcium-dependent mechanism. Increased intracellular calcium levels activate calmodulin-dependent kinase (CaMK), leading to the activation of Egr-1 and subsequent gene expression. | ||||||