Molecular structure of 4α-Phorbol 12,13-didecanoate, CAS Number: 27536-56-7
4α-Phorbol 12,13-didecanoate (CAS 27536-56-7)
See product citations (3)
Alternate Names:
4αPDD
Application:
4α-Phorbol 12,13-didecanoate is an activator of TRPV4
CAS Number:
27536-56-7
Purity:
99%
Molecular Weight:
672.9
Molecular Formula:
C40H64O8
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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4α-Phorbol 12,13-didecanoate is a potent activator of protein kinase C (PKC), a key enzyme involved in signal transduction pathways. It functions by binding to the C1 domain of PKC, leading to its translocation to the cell membrane where it becomes activated. Once activated, PKC phosphorylates a wide range of substrate proteins, modulating their activity and initiating downstream. 4α-Phorbol 12,13-Didecanoate′s mechanism of action involves the regulation of various cellular processes, including cell proliferation, differentiation, and apoptosis. By modulating PKC activity, 4α-Phorbol 12,13-didecanoate may influence gene expression, cytoskeletal organization, and membrane transport, making it useful for studying intracellular signaling pathways and cellular responses to external stimuli.
4α-Phorbol 12,13-didecanoate (CAS 27536-56-7) References
- Heat-evoked activation of TRPV4 channels in a HEK293 cell expression system and in native mouse aorta endothelial cells. | Watanabe, H., et al. 2002. J Biol Chem. 277: 47044-51. PMID: 12354759
- Cell swelling, heat, and chemical agonists use distinct pathways for the activation of the cation channel TRPV4. | Vriens, J., et al. 2004. Proc Natl Acad Sci U S A. 101: 396-401. PMID: 14691263
- A role for AQP5 in activation of TRPV4 by hypotonicity: concerted involvement of AQP5 and TRPV4 in regulation of cell volume recovery. | Liu, X., et al. 2006. J Biol Chem. 281: 15485-95. PMID: 16571723
- Transient receptor potential vanilloid-4 has a major role in visceral hypersensitivity symptoms. | Cenac, N., et al. 2008. Gastroenterology. 135: 937-46, 946.e1-2. PMID: 18565335
- Trpv4 induces collateral vessel growth during regeneration of the arterial circulation. | Troidl, C., et al. 2009. J Cell Mol Med. 13: 2613-2621. PMID: 19017361
- Identification and characterization of novel TRPV4 modulators. | Vincent, F., et al. 2009. Biochem Biophys Res Commun. 389: 490-4. PMID: 19737537
- Functional characterization of TRPV4 as an osmotically sensitive ion channel in porcine articular chondrocytes. | Phan, MN., et al. 2009. Arthritis Rheum. 60: 3028-37. PMID: 19790068
- Cardiac fibroblasts have functional TRPV4 activated by 4alpha-phorbol 12,13-didecanoate. | Hatano, N., et al. 2009. Life Sci. 85: 808-14. PMID: 19879881
- TRPV4 channels augment macrophage activation and ventilator-induced lung injury. | Hamanaka, K., et al. 2010. Am J Physiol Lung Cell Mol Physiol. 299: L353-62. PMID: 20562229
- Transient receptor potential vanilloid 4 activated inflammatory signals by intestinal epithelial cells and colitis in mice. | D'Aldebert, E., et al. 2011. Gastroenterology. 140: 275-85. PMID: 20888819
- Prolonged high fat/alcohol exposure increases TRPV4 and its functional responses in pancreatic stellate cells. | Zhang, LP., et al. 2013. Am J Physiol Regul Integr Comp Physiol. 304: R702-11. PMID: 23447134
- Promoting increased mechanical properties of tissue engineered neocartilage via the application of hyperosmolarity and 4α-phorbol 12,13-didecanoate (4αPDD). | Lee, JK., et al. 2014. J Biomech. 47: 3712-8. PMID: 25442009
- Altered growth properties of normal human cells induced by phorbol 12,13-didecanoate. | Trewyn, RW. and Gatz, HB. 1984. In Vitro. 20: 409-15. PMID: 6724621
Inhibitor of:
δ-casein.Activator of:
ACTR-I, ANKAR, ANKMY1, ANKRD39, C17orf49_0610010K14Rik, CREM, Egr-1, FBL18, L-Plastin, PSK2, TRPM4, TRPV4, VR1, and ZNF98.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4α-Phorbol 12,13-didecanoate, 1 mg | sc-201210 | 1 mg | $188.00 | |||
4α-Phorbol 12,13-didecanoate, 5 mg | sc-201210A | 5 mg | $676.00 |