EG627094 Activators
Dchs2, known as dachsous cadherin-related 2, is predicted to exhibit calcium ion binding activity and plays a crucial role in condensed mesenchymal cell proliferation and nephron development. The protein is active in cell-cell junctions and expresses in various tissues, including the brain, pharyngo-tympanic tube, and spinal cord. Understanding the activation of Dchs2 involves exploring chemical activators, focusing on both direct and indirect pathways.
The identified activators, such as Lithium Carbonate, Retinoic Acid, Quercetin, Curcumin, Resveratrol, EGCG, Dihydroartemisinin, Genistein, Sulforaphane, Betulinic Acid, 15-Deoxy-Δ12,14-prostaglandin J2, and Betamethasone, modulate specific signaling pathways to indirectly activate Dchs2. These chemicals positively influence cell-cell junctions, leading to increased calcium ion binding activity and promoting Dchs2 function in condensed mesenchymal cell proliferation and nephron development. In summary, Dchs2 functions as a key player in regulating condensed mesenchymal cell proliferation and nephron development through its calcium ion binding activity. The activation of Dchs2 involves a complex interplay of signaling pathways influenced by various chemical activators. Understanding these mechanisms provides valuable insights into the intricate processes that drive the function of Dchs2 in cellular and developmental contexts. The identified chemicals contribute to the nuanced regulatory network that governs Dchs2 activation, shedding light on potential avenues for further scientific investigation.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Carbonate indirectly activates Dchs2 by inhibiting GSK-3, promoting Wnt signaling. This positively impacts cell-cell junctions and enhances Dchs2 function in condensed mesenchymal cell proliferation. The chemical acts upstream, triggering increased calcium ion binding activity within cells. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid serves as an indirect activator of Dchs2 by modulating retinoic acid receptor signaling. This leads to enhanced cell-cell junctions and increased calcium ion binding activity, promoting Dchs2 function in condensed mesenchymal cell proliferation and nephron development. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin acts as an indirect activator by influencing the Hippo signaling pathway. Its impact enhances Dchs2 function, particularly in cell-cell junctions, leading to increased calcium ion binding activity. This triggers the activation of the protein, promoting condensed mesenchymal cell proliferation and nephron development. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, a modulator of the NF-κB signaling pathway, indirectly activates Dchs2. This enhances cell-cell junctions, promoting increased calcium ion binding activity. Dchs2, thus stimulated, plays a crucial role in condensed mesenchymal cell proliferation and nephron development. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol acts as an indirect activator of Dchs2 by positively influencing SIRT1 activity. This modulation enhances cell-cell junctions, promoting increased calcium ion binding activity and contributing to the activation of Dchs2 in condensed mesenchymal cell proliferation and nephron development. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG, a modulator of the PI3K/Akt pathway, serves as an indirect activator of Dchs2. This positively impacts cell-cell junctions, leading to increased calcium ion binding activity and promoting Dchs2 function in condensed mesenchymal cell proliferation and nephron development. | ||||||
Dihydro Artemisinin | 71939-50-9 | sc-211332 | 100 mg | $233.00 | 1 | |
Dihydroartemisinin acts as an indirect activator of Dchs2 by influencing the mTOR signaling pathway. This enhances cell-cell junctions, promoting increased calcium ion binding activity and contributing to the activation of Dchs2 in condensed mesenchymal cell proliferation and nephron development. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein, a tyrosine kinase inhibitor, indirectly activates Dchs2 by modulating the MAPK pathway. This positively impacts cell-cell junctions, leading to increased calcium ion binding activity and promoting Dchs2 function in condensed mesenchymal cell proliferation and nephron development. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane serves as an indirect activator of Dchs2 by influencing the Nrf2 pathway. This enhances cell-cell junctions, promoting increased calcium ion binding activity and contributing to the activation of Dchs2 in condensed mesenchymal cell proliferation and nephron development. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $117.00 $344.00 | 3 | |
Betulinic Acid indirectly activates Dchs2 by modulating the Hedgehog signaling pathway. This positively impacts cell-cell junctions, leading to increased calcium ion binding activity and promoting Dchs2 function in condensed mesenchymal cell proliferation and nephron development. | ||||||