EG621697 Activators
Rpl32l, a ribosomal protein L32-like, stands as an integral component in the orchestration of cellular processes, primarily contributing to the machinery of ribosomes and protein synthesis. The primary function of Rpl32l lies in its involvement in the assembly and structure of the ribosome, a fundamental cellular organelle responsible for translating genetic information into functional proteins. As a ribosomal protein, Rpl32l plays a crucial role in the formation of the large ribosomal subunit, participating in the intricate dance of ribosomal components that ensures the fidelity and efficiency of protein synthesis. The ribosome, consisting of both small and large subunits, serves as the cellular workbench where amino acids are strung together to form polypeptide chains, marking the cornerstone of cellular function and integrity. The activation of Rpl32l is intricately regulated by a diverse array of cellular mechanisms that maintain the delicate balance required for optimal ribosomal function. Both direct and indirect activators influence the expression and stability of Rpl32l, ensuring its participation in the cellular machinery. Direct activators, such as those inhibiting RNA polymerase or inducing ribosomal stalling, act at the heart of transcription and translation processes, affecting the production and utilization of Rpl32l. Indirect activators modulate various cellular pathways, such as mTOR signaling, histone acetylation, and epigenetic landscapes, impacting the overall levels of Rpl32l within the cell. These intricate regulatory mechanisms highlight the responsiveness of Rpl32l to various cellular cues, from ribosomal stress to metabolic changes, ensuring a dynamic and adaptive response to the ever-changing cellular environment.
The general mechanisms of Rpl32l activation underscore its role as a sentinel of cellular homeostasis. Ribosomal stress, induced by factors like translational inhibitors or metabolic alterations, triggers compensatory mechanisms that lead to the up-regulation of Rpl32l. This activation ensures the maintenance of ribosomal function and protein synthesis, even under conditions of cellular stress. Additionally, epigenetic modulators and signaling pathway regulators contribute to the fine-tuning of Rpl32l levels, emphasizing its importance in the broader context of cellular regulation. The complexity of these mechanisms reflects the intricate web of cellular responses orchestrated to guarantee the presence and functionality of Rpl32l, a key player in the grand symphony of cellular life.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Indirectly activates Rpl32l by inhibiting mTOR, influencing the mTOR pathway. This leads to enhanced ribosomal biogenesis and increased synthesis of Rpl32l, contributing to elevated levels of this ribosomal protein. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Directly inhibits RNA polymerase, leading to transcriptional repression of ribosomal protein genes, including Rpl32l. Counterintuitively, this inhibition triggers compensatory mechanisms that ultimately result in up-regulation of Rpl32l expression, ensuring sustained ribosomal function. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
Indirectly stimulates Rpl32l by inhibiting proteasomal degradation, ensuring the stability and accumulation of ribosomal proteins. This intervention contributes to the up-regulation of Rpl32l levels within the cell. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
Functions as a DNA demethylating agent, indirectly activating Rpl32l by altering the epigenetic landscape. This epigenetic modulation leads to enhanced transcription of the Rpl32l gene, promoting increased expression of this ribosomal protein. | ||||||
Torin 1 | 1222998-36-8 | sc-396760 | 10 mg | $240.00 | 7 | |
Acts as an mTOR inhibitor, indirectly promoting Rpl32l activation by modulating the mTOR signaling pathway. This regulation contributes to increased ribosomal biogenesis and elevated levels of Rpl32l within the cell. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Indirectly activates Rpl32l by inhibiting histone deacetylases, leading to histone hyperacetylation and altered chromatin structure around the Rpl32l gene. This epigenetic modification facilitates enhanced transcription, resulting in increased expression of Rpl32l. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Inhibits protein synthesis, leading to ribosomal stress and activation of compensatory mechanisms. This includes up-regulation of Rpl32l expression, ensuring a balance in ribosomal protein levels despite the general protein synthesis inhibition induced by Cycloheximide. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $65.00 $210.00 | 26 | |
Indirectly activates Rpl32l by inhibiting glycolysis, triggering the AMP-activated protein kinase (AMPK) pathway. AMPK activation subsequently modulates cellular processes that contribute to the up-regulation of Rpl32l, ensuring sustained ribosomal function under metabolic stress conditions. | ||||||
Puromycin | 53-79-2 | sc-205821 sc-205821A | 10 mg 25 mg | $163.00 $316.00 | 436 | |
Incorporates into nascent polypeptide chains during translation, leading to premature termination and ribosomal stalling. This ribosomal stress activates cellular responses, including the up-regulation of Rpl32l, ensuring a compensatory increase in ribosomal protein levels to maintain cellular homeostasis. | ||||||
Nutlin-3 | 548472-68-0 | sc-45061 sc-45061A sc-45061B | 1 mg 5 mg 25 mg | $56.00 $212.00 $764.00 | 24 | |
Indirectly influences Rpl32l by disrupting the interaction between p53 and MDM2, leading to p53 activation. Activated p53, in turn, modulates cellular processes that contribute to the up-regulation of Rpl32l, ensuring sustained ribosomal function under conditions of cellular stress and DNA damage. | ||||||