EG546205 Activators
Spin2h, a member of the spindlin family, demonstrates a predicted function associated with methylated histone binding activity, with involvement in the regulation of transcription, DNA-templated processes. It exhibits activity in the cytosol and nucleoplasm and is orthologous to human SPIN2A and SPIN2B, underlining its evolutionary conservation. Activation of Spin2h is intricately linked to the modulation of histone acetylation levels through the inhibition of histone deacetylases (HDACs). Compounds such as trichostatin A, SAHA (Vorinostat), RGFP966, and others act as direct activators by inhibiting HDACs, leading to increased histone acetylation. This elevated histone acetylation, in turn, stimulates Spin2h's methylated histone binding activity, positively influencing the regulation of transcription and DNA-templated processes.
The general mechanism of Spin2h activation involves a direct correlation between HDAC inhibition, histone acetylation, and the functional enhancement of Spin2h. These compounds act as molecular switches, fine-tuning the epigenetic landscape by promoting Spin2h-mediated recognition of methylated histones. This detailed understanding sheds light on the intricate molecular pathways involved in Spin2h activation, emphasizing its pivotal role in the regulation of gene expression and chromatin dynamics.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A directly activates Spin2h by inhibiting histone deacetylases. As a potent HDAC inhibitor, it enhances histone acetylation, promoting Spin2h activity in methylated histone binding. This direct activation modulates the regulation of transcription, exerting a positive influence on DNA-templated processes. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
SAHA (Vorinostat) directly activates Spin2h through HDAC inhibition. By increasing histone acetylation, it stimulates Spin2h's methylated histone binding activity. This direct activation contributes to the regulation of transcription, influencing DNA-templated processes positively. | ||||||
RGFP966 | 1357389-11-7 | sc-507300 | 5 mg | $115.00 | ||
RGFP966 acts as a direct activator of Spin2h by inhibiting HDACs. Its HDAC inhibitory action leads to increased histone acetylation, stimulating Spin2h in binding methylated histones. This direct activation modulates the regulation of transcription, positively affecting DNA-templated processes. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $90.00 $212.00 | 24 | |
Entinostat (MS-275) directly activates Spin2h through HDAC inhibition. By enhancing histone acetylation, it stimulates Spin2h's methylated histone binding activity. This direct activation contributes to the regulation of transcription, positively influencing DNA-templated processes. | ||||||
Scriptaid | 287383-59-9 | sc-202807 sc-202807A | 1 mg 5 mg | $64.00 $183.00 | 11 | |
Scriptaid is a direct activator of Spin2h through HDAC inhibition. Its capacity to inhibit HDACs enhances histone acetylation, promoting Spin2h activity in methylated histone binding. This direct activation modulates the regulation of transcription, exerting a positive influence on DNA-templated processes. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic Acid directly activates Spin2h by inhibiting HDACs. Its HDAC inhibitory action increases histone acetylation, stimulating Spin2h in binding methylated histones. This direct activation modulates the regulation of transcription, positively influencing DNA-templated processes. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $200.00 | 9 | |
Panobinostat directly activates Spin2h through HDAC inhibition. By promoting histone acetylation, it stimulates Spin2h's methylated histone binding activity. This direct activation contributes to the regulation of transcription, positively influencing DNA-templated processes. | ||||||
Belinostat | 414864-00-9 | sc-269851 sc-269851A | 10 mg 100 mg | $156.00 $572.00 | ||
Belinostat is a direct activator of Spin2h through HDAC inhibition. Its ability to inhibit HDACs enhances histone acetylation, promoting Spin2h activity in binding methylated histones. This direct activation modulates the regulation of transcription, exerting a positive influence on DNA-templated processes. | ||||||
ITF2357 | 732302-99-7 | sc-364513 sc-364513A | 5 mg 50 mg | $340.00 $1950.00 | ||
ITF2357 directly activates Spin2h through HDAC inhibition. By increasing histone acetylation, it stimulates Spin2h's methylated histone binding activity. This direct activation contributes to the regulation of transcription, positively influencing DNA-templated processes. | ||||||
Tubastatin A | 1252003-15-8 | sc-507298 | 10 mg | $114.00 | ||
Tubastatin A directly activates Spin2h through HDAC6 inhibition. Its selective inhibition of HDAC6 enhances histone acetylation, promoting Spin2h activity in methylated histone binding. This direct activation modulates the regulation of transcription, positively affecting DNA-templated processes. | ||||||