EG434179 Activators
Zfp975, a zinc finger protein, emerges as a pivotal player in the orchestration of embryonic development and gene regulation. Functioning as a DNA-binding transcription factor, Zfp975 intricately regulates transcription by RNA polymerase II within the nucleus. Its predicted localization in the nucleus underscores its significance in the control of cellular processes during embryogenesis.
The activation of Zfp975 is finely tuned by a repertoire of chemicals acting as direct activators. Trichostatin A, retinoic acid, curcumin, 5-azacytidine, dimethyl sulfoxide, JQ1, epigallocatechin gallate, sodium butyrate, vorinostat, alpha-lipoic acid, sanguinarine, and aza-2'-deoxycytidine collectively modulate epigenetic modifications, chromatin accessibility, and redox signaling pathways. These activators enhance Zfp975's DNA-binding transcription factor activity, promoting its role in the intricate regulation of gene expression during embryonic development. The up-regulation of Zfp975 supports its crucial involvement in transcriptional processes, contributing to the dynamic landscape of gene regulation within the nucleus. In summary, Zfp975 stands as a central regulator in embryonic development, utilizing its DNA-binding transcription factor activity to modulate RNA polymerase II-mediated transcription. The identified activators offer a glimpse into the sophisticated regulatory network governing Zfp975, providing avenues for further exploration into the intricacies of gene expression and embryonic development.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A acts as a direct activator of Zfp975 by inhibiting histone deacetylases (HDACs). This enhances DNA accessibility, promoting Zfp975 binding to cis-regulatory regions. The up-regulation of Zfp975 expression supports its role as a DNA-binding transcription factor, regulating transcription by RNA polymerase II within the nucleus, contributing to embryonic development and gene regulation. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid serves as a direct activator of Zfp975 by interacting with retinoic acid response elements. This leads to enhanced DNA-binding activity, promoting Zfp975-mediated transcriptional regulation. The up-regulation of Zfp975 supports its involvement in the regulation of transcription by RNA polymerase II, contributing to embryonic development and gene regulation within the nucleus. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin acts as a direct activator of Zfp975 by modulating the activity of transcription factors. It enhances the binding of Zfp975 to cis-regulatory regions, influencing RNA polymerase II-mediated transcription. The up-regulation of Zfp975 expression supports its role in the regulation of transcription by RNA polymerase II within the nucleus, contributing to embryonic development and gene regulation. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine serves as a direct activator of Zfp975 by inhibiting DNA methylation. This promotes an open chromatin state, facilitating Zfp975 binding to cis-regulatory regions. The up-regulation of Zfp975 expression supports its role in RNA polymerase II-specific DNA binding, contributing to the regulation of transcription within the nucleus and influencing embryonic development and gene expression. | ||||||
Dimethyl Sulfoxide (DMSO) | 67-68-5 | sc-202581 sc-202581A sc-202581B | 100 ml 500 ml 4 L | $30.00 $115.00 $900.00 | 136 | |
Dimethyl sulfoxide acts as a direct activator of Zfp975 by modulating epigenetic modifications. It enhances DNA-binding transcription factor activity, promoting Zfp975-mediated transcriptional regulation. The up-regulation of Zfp975 supports its role in the regulation of transcription by RNA polymerase II within the nucleus, contributing to embryonic development and gene regulation. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $226.00 $846.00 | 1 | |
JQ1 serves as a direct activator of Zfp975 by inhibiting bromodomain-containing proteins. This enhances Zfp975 binding to acetylated chromatin, influencing RNA polymerase II-specific DNA binding. The up-regulation of Zfp975 expression supports its involvement in transcriptional regulation, contributing to embryonic development and gene regulation within the nucleus. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin gallate acts as a direct activator of Zfp975 by influencing epigenetic modifications. It enhances the binding of Zfp975 to cis-regulatory regions, promoting RNA polymerase II-specific DNA binding. The up-regulation of Zfp975 expression supports its role in transcriptional regulation within the nucleus, contributing to embryonic development and gene expression. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate acts as a direct activator of Zfp975 by inhibiting histone deacetylases (HDACs). This enhances Zfp975 binding to cis-regulatory regions, influencing RNA polymerase II-mediated transcription. The up-regulation of Zfp975 supports its role in the regulation of transcription by RNA polymerase II within the nucleus, contributing to embryonic development and gene regulation. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Suberoylanilide Hydroxamic Acid acts as a direct activator of Zfp975 by inhibiting histone deacetylases (HDACs). This enhances DNA accessibility, promoting Zfp975 binding to cis-regulatory regions. The up-regulation of Zfp975 expression supports its role as a DNA-binding transcription factor, regulating transcription by RNA polymerase II within the nucleus, contributing to embryonic development and gene regulation. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $68.00 $120.00 $208.00 $373.00 $702.00 | 3 | |
Alpha-lipoic acid serves as a direct activator of Zfp975 by influencing redox signaling pathways. It enhances DNA-binding transcription factor activity, promoting Zfp975-mediated transcriptional regulation. The up-regulation of Zfp975 supports its involvement in the regulation of transcription by RNA polymerase II within the nucleus, contributing to embryonic development and gene regulation. | ||||||