EG434123 Activators
Obox8, an oocyte-specific homeobox gene, exhibits a multifaceted role in cellular processes by virtue of its predicted DNA-binding transcription factor activity, specifically associated with RNA polymerase II. Engaged in RNA polymerase II cis-regulatory region sequence-specific DNA binding, Obox8 plays a pivotal role in the regulation of transcription processes within the cell. Activation of Obox8 is intricately governed by a spectrum of chemicals that serve as direct activators, modulating various cellular pathways and processes. These include trichostatin A, retinoic acid, curcumin, 5-azacytidine, dimethyl sulfoxide, JQ1, epigallocatechin gallate, sodium butyrate, vorinostat, alpha-lipoic acid, sanguinarine, and aza-2'-deoxycytidine. These activators influence epigenetic modifications, chromatin accessibility, and redox signaling, collectively enhancing Obox8's DNA-binding transcription factor activity. The up-regulation of Obox8 expression supports its pivotal role in the regulation of RNA polymerase II-mediated transcription, contributing to the intricate orchestration of cellular gene expression patterns.
In summary, Obox8 emerges as a key player in the cellular landscape, orchestrating transcriptional regulation by RNA polymerase II. The direct activation by specific chemicals highlights its specificity in influencing diverse cellular processes, underscoring its significance in the intricate network of gene expression regulation. This comprehensive understanding of Obox8 and its activation mechanisms provides a foundation for further exploration of its physiological functions within the dynamic cellular milieu.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A acts as a direct activator of Obox8 by inhibiting histone deacetylases (HDACs). This enhances DNA accessibility, promoting Obox8 binding to cis-regulatory regions. The up-regulation of Obox8 expression supports its role as a transcription factor, regulating RNA polymerase II-mediated transcription within specific genomic regions. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid serves as a direct activator of Obox8 by interacting with retinoic acid response elements. This leads to enhanced DNA-binding activity, promoting Obox8-mediated transcriptional regulation. The up-regulation of Obox8 supports its involvement in RNA polymerase II-specific cis-regulatory region sequence-specific DNA binding, influencing gene expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin acts as a direct activator of Obox8 by modulating the activity of transcription factors. It enhances the binding of Obox8 to cis-regulatory regions, influencing RNA polymerase II-mediated transcription. The up-regulation of Obox8 expression supports its role in the regulation of transcription by RNA polymerase II, contributing to cellular transcriptional processes. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine serves as a direct activator of Obox8 by inhibiting DNA methylation. This promotes an open chromatin state, facilitating Obox8 binding to cis-regulatory regions. The up-regulation of Obox8 expression supports its role in RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activities, influencing transcriptional regulation. | ||||||
Dimethyl Sulfoxide (DMSO) | 67-68-5 | sc-202581 sc-202581A sc-202581B | 100 ml 500 ml 4 L | $31.00 $117.00 $918.00 | 136 | |
Dimethyl sulfoxide acts as a direct activator of Obox8 by modulating epigenetic modifications. It enhances DNA-binding transcription factor activity, promoting Obox8-mediated transcriptional regulation. The up-regulation of Obox8 expression supports its role in the regulation of transcription by RNA polymerase II within specific genomic regions. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
JQ1 serves as a direct activator of Obox8 by inhibiting bromodomain-containing proteins. This enhances Obox8 binding to acetylated chromatin, influencing RNA polymerase II-specific cis-regulatory region sequence-specific DNA binding. The up-regulation of Obox8 expression supports its involvement in transcriptional regulation, impacting the regulation of genes associated with cellular processes. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin gallate acts as a direct activator of Obox8 by influencing epigenetic modifications. It enhances the binding of Obox8 to cis-regulatory regions, promoting RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activities. The up-regulation of Obox8 expression supports its role in transcriptional regulation, influencing gene expression patterns. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate acts as a direct activator of Obox8 by inhibiting histone deacetylases (HDACs). This enhances Obox8 binding to cis-regulatory regions, influencing RNA polymerase II-mediated transcription. The up-regulation of Obox8 expression supports its role in the regulation of transcription by RNA polymerase II, contributing to cellular transcriptional processes. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Suberoylanilide Hydroxamic Acid acts as a direct activator of Obox8 by inhibiting histone deacetylases (HDACs). This enhances DNA accessibility, promoting Obox8 binding to cis-regulatory regions. The up-regulation of Obox8 expression supports its role as a transcription factor, regulating RNA polymerase II-mediated transcription within specific genomic regions. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $69.00 $122.00 $212.00 $380.00 $716.00 | 3 | |
Alpha-lipoic acid serves as a direct activator of Obox8 by influencing redox signaling pathways. It enhances DNA-binding transcription factor activity, promoting Obox8-mediated transcriptional regulation. The up-regulation of Obox8 expression supports its involvement in RNA polymerase II-specific cis-regulatory region sequence-specific DNA binding, influencing gene expression. | ||||||