EG245651 Activators
Gm4995, a predicted gene with DNA-binding transcription factor activity specific to RNA polymerase II transcription regulatory regions, plays a crucial role in governing gene expression within the cellular landscape. Positioned as a key player in the intricate regulatory network, Gm4995 orchestrates transcriptional machinery, exerting influence over the fate of downstream genes. Its predicted involvement in the regulation of transcription by RNA polymerase II underscores its significance in shaping the cellular processes that govern transcription.
The activation of Gm4995 involves a sophisticated interplay of various chemical modulators, each targeting specific cellular pathways that either directly or indirectly impact its DNA-binding transcription factor activity. These pathways, including retinoic acid signaling, histone modification, cAMP elevation, and MAPK cascades, contribute to the nuanced regulation of Gm4995. The intricate network of activation mechanisms highlights the adaptability of Gm4995 to respond to diverse intracellular signals and environmental cues, underscoring its role as a central regulator in the fine-tuning of gene expression. The interplay between chemical modulators and Gm4995 provides insights into the complex regulatory dynamics governing transcriptional processes, emphasizing the multifaceted nature of gene expression control within the cellular milieu.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Up-regulates Gm4995 by binding to retinoic acid receptors, influencing DNA-binding transcription factor activity specific to RNA polymerase II. Enhances transcriptional regulatory functions. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
HDAC inhibitor impacting chromatin structure, indirectly promoting Gm4995. Enhances DNA-binding specificity to RNA polymerase II regulatory regions. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Alters histone acetylation, promoting Gm4995 function. Enhances DNA-binding specificity to RNA polymerase II transcription regulatory regions. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
MEK inhibitor affecting MAPK pathway, indirectly promoting Gm4995. Alters intracellular signaling cascades, enhancing DNA-binding to RNA polymerase II regulatory regions. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
PI3K inhibitor affecting PI3K/Akt pathway, indirectly up-regulating Gm4995. Modulates intracellular signaling, promoting DNA-binding transcription factor activity specific to RNA polymerase II. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
p38 MAPK inhibitor influencing MAPK pathway, indirectly enhancing Gm4995. Alters cellular signaling cascades, promoting DNA-binding to RNA polymerase II transcription regulatory regions. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
BET inhibitor affecting bromodomain proteins, promoting Gm4995 activity. Modulates chromatin structure, enhancing DNA-binding transcription factor activity specific to RNA polymerase II regulatory regions. | ||||||
BIX01294 hydrochloride | 1392399-03-9 | sc-293525 sc-293525A sc-293525B | 1 mg 5 mg 25 mg | $37.00 $112.00 $408.00 | ||
G9a inhibitor affecting histone methylation, promoting Gm4995 function. Modulates epigenetic marks, enhancing DNA-binding transcription factor activity specific to RNA polymerase II regulatory regions. | ||||||
NSC 668036 | 144678-63-7 | sc-507412 | 5 mg | $175.00 | ||
Dvl PDZ domain inhibitor impacting Wnt signaling, indirectly promoting Gm4995. Alters Dishevelled function, enhancing DNA-binding to RNA polymerase II transcription regulatory regions. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Enhances Gm4995 activity by activating SIRT1, influencing DNA-binding transcription factor activity specific to RNA polymerase II transcription regulatory regions. Modulates cellular pathways, promoting transcriptional regulatory functions. | ||||||