EG243302 Activators
Gm4963, a predicted gene with functional characteristics akin to IFI16, stands as a pivotal orchestrator in cellular processes governing gene expression and the regulation of the innate immune response. With attributed DNA-binding transcription repressor activity, RNA polymerase II-specific DNA binding activity, and identical protein binding activity, Gm4963 is primarily localized within the nucleolus and nucleoplasm. Its multifaceted role is evident in the regulation of cysteine-type endopeptidase activity and the innate immune response, underscoring its significance in maintaining cellular homeostasis. The activation of Gm4963 involves intricate signaling pathways influenced by specific biochemical modulators. These activators impact Gm4963 directly or indirectly, emphasizing the diverse mechanisms by which this gene is regulated. Various compounds, acting through different signaling pathways, contribute to the up-regulation, stimulation, enhancement, and promotion of Gm4963. For instance, the activation of Gm4963 through the SIRT1/AMPK pathway by Resveratrol highlights its involvement in DNA binding and nucleolar functions. Modulation of NF-κB signaling by Quercetin showcases the intricate crosstalk between Gm4963 and innate immune responses within the nucleoplasm.
Moreover, Gm4963 activation is influenced by compounds such as Ursolic Acid through the mTOR pathway, emphasizing its role in RNA polymerase II-specific DNA binding and gene expression regulation. Triggering Gm4963 through TLR4 signaling by Curcumin elucidates its impact on cysteine-type endopeptidase activity and innate immune responses. The activation via the JNK signaling pathway by Carnosic Acid further emphasizes Gm4963's involvement in identical protein binding and nucleolus-associated functions. These diverse pathways collectively contribute to the intricate regulation of Gm4963, highlighting its central role in cellular homeostasis and the modulation of key cellular activities.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a polyphenolic compound, activates Gm4963 by influencing the SIRT1/AMPK pathway. It enhances Gm4963 expression, promoting cellular homeostasis through its role in regulating DNA binding and nucleolus-associated activities. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin, a flavonoid, acts as an indirect activator by modulating the NF-κB signaling pathway. This leads to the up-regulation of Gm4963, contributing to the regulation of innate immune responses and gene expression within the nucleoplasm. | ||||||
Ursolic Acid | 77-52-1 | sc-200383 sc-200383A | 50 mg 250 mg | $56.00 $180.00 | 8 | |
Ursolic Acid promotes Gm4963 activation through the mTOR signaling pathway. It enhances RNA polymerase II-specific DNA binding activity, modulating cellular processes associated with gene expression and reinforcing the nucleolar function of Gm4963. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin serves as a direct activator, influencing the TLR4 signaling pathway. It triggers Gm4963, impacting cellular activities related to the regulation of cysteine-type endopeptidase activity and reinforcing its role in innate immune response regulation. | ||||||
Carnosic acid | 3650-09-7 | sc-202520 sc-202520A | 10 mg 50 mg | $75.00 $221.00 | 6 | |
Carnosic Acid, a natural phenolic compound, activates Gm4963 by modulating the JNK signaling pathway. This leads to enhanced identical protein binding activity, influencing cellular processes involved in gene expression and maintaining nucleoplasmic functions. | ||||||
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $27.00 $51.00 $101.00 $153.00 $1925.00 | 40 | |
Luteolin, a flavone, acts as an indirect activator through the PI3K/Akt pathway. It stimulates Gm4963 expression, playing a role in the regulation of innate immune responses and gene expression within the nucleolus and nucleoplasm. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein activates Gm4963 by influencing the ERK signaling pathway. It triggers cellular processes associated with gene expression and nucleoplasmic functions, contributing to the regulation of cysteine-type endopeptidase activity and the innate immune response. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane, an isothiocyanate, serves as a direct activator by targeting the Nrf2 signaling pathway. It up-regulates Gm4963, reinforcing its role in cellular homeostasis and influencing DNA binding transcription repressor activity within the nucleolus and nucleoplasm. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin Gallate activates Gm4963 through modulation of the Wnt signaling pathway. It enhances identical protein binding activity, impacting cellular processes related to gene expression and nucleolus-associated activities, supporting the overall role of Gm4963. | ||||||
Piperine | 94-62-2 | sc-205809 sc-205809A | 5 g 25 g | $37.00 $146.00 | 3 | |
Piperine, an alkaloid, acts as an indirect activator through the Notch signaling pathway. It promotes Gm4963 expression, contributing to the regulation of innate immune responses and gene expression within the nucleoplasm, reinforcing its significance in cellular processes. | ||||||