Date published: 2026-3-11

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EDG-4 Activators

EDG-4 activators, part of a broader category of bioactive molecules, specifically interact with the EDG-4 receptor, a member of the endothelial differentiation gene (EDG) family of receptors. This family predominantly comprises G protein-coupled receptors (GPCRs), known for their pivotal roles in cellular communication and signal transduction. The EDG-4 receptor, also known as LPA3, responds to lipid signaling molecules and is a crucial component in a range of cellular processes. Activators of EDG-4, therefore, are compounds that can bind to and stimulate this receptor, initiating a cascade of intracellular events. The chemical nature of these activators is diverse, often encompassing lipids like sphingosine-1-phosphate (S1P) and its analogs or derivatives, which are naturally occurring or synthetically modified to enhance interaction with EDG-4. The function of EDG-4 activators is centered around their binding affinity and subsequent activation of the EDG-4 receptor. Once engaged, these activators trigger a series of signal transduction pathways that can affect various aspects of cell behavior, including migration, proliferation, and survival. The specificity and efficacy of these activators are crucial, as they determine the extent and nature of the receptor-mediated response. Research in this domain delves into understanding the molecular dynamics of EDG-4-ligand interactions, exploring how these activators influence receptor conformation and signaling pathways. Moreover, the study of EDG-4 activators extends into exploring the structure-activity relationships, aiming to decipher how modifications in the chemical structure of these molecules impact their receptor binding and activating capabilities. The evolving understanding of these activators is thus fundamental in comprehending the complex signaling networks mediated by GPCRs like EDG-4, contributing significantly to the field of cellular and molecular biology.

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Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Lysophosphatidic Acid

325465-93-8sc-201053
sc-201053A
5 mg
25 mg
$98.00
$341.00
50
(3)

Lysophosphatidic Acid (CAS 325465-93-8) is a naturally occurring bioactive phospholipid known to activate the EDG-4 receptor (LPA3). As an EDG-4 activator, it plays a significant role in cellular signaling, impacting processes like cell proliferation, migration, and survival by binding to and activating this specific G protein-coupled receptor, thereby initiating a cascade of intracellular events.

D-erythro-Sphingosine-1-phosphate

26993-30-6sc-201383
sc-201383D
sc-201383A
sc-201383B
sc-201383C
1 mg
2 mg
5 mg
10 mg
25 mg
$165.00
$322.00
$570.00
$907.00
$1727.00
7
(1)

D-erythro-Sphingosine-1-phosphate (CAS 26993-30-6) is a bioactive lipid that functions as an activator of the EDG-4 receptor (LPA3). Its role primarily involves binding to and activating EDG-4, thereby modulating various cellular functions related to the signaling pathways associated with this receptor.

FTY720 Phosphate

402615-91-2sc-205332
sc-205332A
1 mg
5 mg
$181.00
$825.00
6
(1)

FTY720 Phosphate (CAS 402615-91-2) is a compound known to interact with several sphingosine-1-phosphate (S1P) receptors, including EDG-4. It functions by binding to EDG-4, potentially influencing the receptor's signaling pathways, which are involved in various cellular processes. However, FTY720 Phosphate's specificity and direct role as an activator of EDG-4 may require further elucidation.

FTY720

162359-56-0sc-202161
sc-202161A
sc-202161B
1 mg
5 mg
25 mg
$33.00
$77.00
$120.00
14
(1)

As a sphingosine-1-phosphate analog, it could modulate sphingolipid pathways and potentially influence EDG-4 expression.

FTY720 (S)-Phosphate

402616-26-6sc-205331
sc-205331A
500 µg
1 mg
$113.00
$218.00
3
(1)

FTY720 (S)-Phosphate (CAS 402616-26-6) acts as a modulator of the EDG-4 receptor. It interacts with this receptor, potentially affecting the signaling pathways governed by EDG-4. This interaction is key in modulating various cellular responses related to the receptor's activity, although the exact mechanism and specificity of this interaction may require further investigation.

Dodecylphosphate

2627-35-2sc-221566
sc-221566A
5 mg
25 mg
$152.00
$561.00
(0)

As of my last update in April 2023, Dodecylphosphate (CAS 2627-35-2) is not specifically documented as an activator of the EDG-4 receptor. Dodecylphosphate is a chemical compound known for its surfactant properties, but its direct interaction with or activation of G protein-coupled receptors like EDG-4 is not well-established in scientific literature. More research may be needed to ascertain its role, if any, in this context.

D-erythro-Sphingosine

123-78-4sc-3546
sc-3546A
sc-3546B
sc-3546C
sc-3546D
sc-3546E
10 mg
25 mg
100 mg
1 g
5 g
10 g
$90.00
$194.00
$510.00
$2448.00
$9384.00
$15300.00
2
(2)

Being part of the sphingolipid pathway, sphingosine might affect EDG-4 expression through interconnected lipid signaling pathways.

Forskolin

66575-29-9sc-3562
sc-3562A
sc-3562B
sc-3562C
sc-3562D
5 mg
50 mg
1 g
2 g
5 g
$78.00
$153.00
$740.00
$1413.00
$2091.00
73
(3)

By elevating cAMP levels, forskolin can modulate GPCR expression, possibly affecting EDG-4.

Dexamethasone

50-02-2sc-29059
sc-29059B
sc-29059A
100 mg
1 g
5 g
$91.00
$139.00
$374.00
36
(1)

This glucocorticoid can modulate various signaling pathways, potentially influencing EDG-4 expression.

Retinoic Acid, all trans

302-79-4sc-200898
sc-200898A
sc-200898B
sc-200898C
500 mg
5 g
10 g
100 g
$66.00
$325.00
$587.00
$1018.00
28
(1)

Known to regulate gene expression, retinoic acid might affect the transcription of GPCRs, including EDG-4.