Date published: 2026-4-25

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EDG-4 Inhibitors

EDG-4 inhibitors are a class of chemical compounds that specifically target and inhibit the activity of the EDG-4 receptor, also known as the sphingosine-1-phosphate receptor 4 (S1P4). EDG-4 is part of the larger family of G-protein-coupled receptors (GPCRs) that play a crucial role in cellular signaling by binding to the bioactive lipid sphingosine-1-phosphate (S1P). This receptor is primarily expressed in the immune system, including lymphoid tissues and certain leukocyte populations, where it is involved in regulating immune cell trafficking, proliferation, and cytokine release. By inhibiting EDG-4, these compounds interfere with the receptor's ability to transmit signals initiated by S1P binding, thereby affecting downstream signaling pathways and cellular responses associated with S1P. The mechanism of action for EDG-4 inhibitors typically involves binding to the receptor's ligand-binding pocket or allosteric sites, preventing the activation of the receptor by S1P. This inhibition blocks the associated G-protein signaling cascades, which can include pathways like the MAPK/ERK pathway, PI3K/AKT pathway, and other signaling networks that control cell migration, survival, and differentiation. Disrupting these pathways through EDG-4 inhibition can lead to altered immune cell behavior, including reduced migration to sites of inflammation or changes in immune cell activation states. Furthermore, EDG-4 inhibitors may influence broader physiological processes where S1P signaling is critical, such as vascular development, lymphocyte circulation, and the maintenance of endothelial barrier function. Studying the effects of EDG-4 inhibition provides valuable insights into the role of this receptor in immune regulation and other S1P-mediated processes, contributing to a deeper understanding of how lipid signaling pathways are integrated into the broader context of cellular and systemic physiology.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Ki16425

355025-24-0sc-221788
sc-221788A
1 mg
5 mg
$199.00
$612.00
17
(1)

Ki16425, an EDG-4 compound, is characterized by its selective binding affinity to specific receptors, which modulates intracellular signaling pathways. Its unique structural features enable it to engage in hydrogen bonding and hydrophobic interactions, influencing molecular conformation and stability. The compound exhibits distinct kinetic behavior, with rapid association and dissociation rates, allowing for dynamic regulation of biological processes. Its solubility properties further enhance its interaction with diverse biomolecular environments.

Tetradecyl Phosphonate

4671-75-4sc-205519
sc-205519A
100 mg
500 mg
$24.00
$115.00
(0)

Tetradecyl Phosphonate, classified as an EDG-4 compound, showcases remarkable molecular interactions through its phosphonate group, facilitating strong dipole-dipole interactions and potential coordination with metal ions. Its long hydrophobic alkyl chain enhances membrane permeability, promoting unique aggregation behaviors in lipid environments. The compound's reactivity is characterized by its ability to undergo nucleophilic substitution, leading to diverse synthetic pathways and influencing reaction kinetics in various chemical contexts.

IP3K Inhibitor Inhibitor

519178-28-0sc-204015
5 mg
$195.00
(0)

IP3K Inhibitor (TNP) is a benzothiazol compound that acts as a DAPK inhibitor. Through its interaction with DAPK, TNP inhibits the kinase activity of DAPK, disrupting its downstream signaling pathways and cellular functions.

CGP-60474

164658-13-3sc-507525
5 mg
$165.00
(0)

CGP-60474 is a pyrazolopyrimidine derivative that acts as a DAPK inhibitor. By interfering with the catalytic activity of DAPK, CGP-60474 directly modulates the downstream signaling pathways and cellular processes regulated by DAPK.

JNJ-38877605

943540-75-8sc-364516
sc-364516A
2 mg
10 mg
$126.00
$365.00
1
(0)

JNJ-38877605 is a pyrazolopyrimidine derivative that acts as a DAPK inhibitor. By interfering with the kinase activity of DAPK, JNJ-38877605 directly modulates the downstream signaling pathways and cellular processes regulated by DAPK. The specific targeting of DAPK by JNJ-38877605 provides a focused approach to interfere with DAPK-mediated effects on cellular functions and regulatory mechanisms.