Molecular structure of FTY720 Phosphate, CAS Number: 402615-91-2
FTY720 Phosphate (CAS 402615-91-2)
See product citations (6)
Alternate Names:
2- amino- 2[2- (4- octylphenyl)ethyl]- 1, 3- propanediol, mono dihydrogen phosphate ester
Application:
FTY720 Phosphate is a derivative of ISP-1 that is a fungal metabolite as well as a structural analog of sphingosine
CAS Number:
402615-91-2
Purity:
>98%
Molecular Weight:
387.50
Molecular Formula:
C19H34NO5P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
FTY720 Phosphate is a derivative of ISP-1 (myriocin) that is a fungal metabolite of the Chinese herb Iscaria sinclarii and a structural analog of sphingosine. FTY720 is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs. It is phosphorylated by sphingosine kinase to the physiologically active phosphoric acid ester. FTY720 phosphate acts as a potent agonist at four of the sphingosine-1-phosphate (S1P) receptors (EDG-1, EDG-3, EDG-4, and EDG-5), with IC50 values of 0.2-6 nM.
FTY720 Phosphate (CAS 402615-91-2) References
- Asymmetric synthesis and biological evaluation of the enantiomeric isomers of the immunosuppressive FTY720-phosphate. | Kiuchi, M., et al. 2005. Bioorg Med Chem. 13: 425-32. PMID: 15598563
- Immunosuppressive activity of FTY720, sphingosine 1-phosphate receptor agonist: I. Prevention of allograft rejection in rats and dogs by FTY720 and FTY720-phosphate. | Chiba, K., et al. 2005. Transplant Proc. 37: 102-6. PMID: 15808561
- Sphingosine 1-phosphate receptor agonist FTY720-phosphate causes marginal zone B cell displacement. | Vora, KA., et al. 2005. J Leukoc Biol. 78: 471-80. PMID: 15894589
- FTY720, a new class of immunomodulator, inhibits lymphocyte egress from secondary lymphoid tissues and thymus by agonistic activity at sphingosine 1-phosphate receptors. | Chiba, K. 2005. Pharmacol Ther. 108: 308-19. PMID: 15951022
- The immune modulator FTY720 inhibits sphingosine-1-phosphate lyase activity. | Bandhuvula, P., et al. 2005. J Biol Chem. 280: 33697-700. PMID: 16118221
- FTY720-phosphate is dephosphorylated by lipid phosphate phosphatase 3. | Mechtcheriakova, D., et al. 2007. FEBS Lett. 581: 3063-8. PMID: 17555747
- Selective activation of G alpha i mediated signalling of S1P3 by FTY720-phosphate. | Sensken, SC., et al. 2008. Cell Signal. 20: 1125-33. PMID: 18313900
- Anticancer activity of FTY720: phosphorylated FTY720 inhibits autotaxin, a metastasis-enhancing and angiogenic lysophospholipase D. | van Meeteren, LA., et al. 2008. Cancer Lett. 266: 203-8. PMID: 18378389
- A splicing isoform of LPP1, LPP1a, exhibits high phosphatase activity toward FTY720 phosphate. | Yamanaka, M., et al. 2008. Biochem Biophys Res Commun. 375: 675-9. PMID: 18755152
- Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors. | Mullershausen, F., et al. 2009. Nat Chem Biol. 5: 428-34. PMID: 19430484
- LC-MS/MS determination of FTY720 and FTY720-phosphate in murine intracellular compartments and human plasma. | Ferreirós, N., et al. 2012. J Chromatogr B Analyt Technol Biomed Life Sci. 887-888: 122-7. PMID: 22341683
- Subcellular distribution of FTY720 and FTY720-phosphate in immune cells - another aspect of Fingolimod action relevant for therapeutic application. | Schröder, M., et al. 2015. Biol Chem. 396: 795-802. PMID: 25720062
- FTY720 Phosphate Activates Sphingosine-1-Phosphate Receptor 2 and Selectively Couples to Gα12/13/Rho/ROCK to Induce Myofibroblast Contraction. | Sobel, K., et al. 2015. Mol Pharmacol. 87: 916-27. PMID: 25762025
- Effect of FTY720-phosphate on the expression of inflammation-associated molecules in astrocytes in vitro. | Janssen, S., et al. 2015. Mol Med Rep. 12: 6171-7. PMID: 26239526
- Elevated Nuclear and Cytoplasmic FTY720-Phosphate in Mouse Embryonic Fibroblasts Suggests the Potential for Multiple Mechanisms in FTY720-Induced Neural Tube Defects. | Gardner, NM., et al. 2016. Toxicol Sci. 150: 161-8. PMID: 26719367
Activator of:
EDG-1, EDG-3, EDG-4, and EDG-5.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FTY720 Phosphate, 1 mg | sc-205332 | 1 mg | $181.00 | |||
FTY720 Phosphate, 5 mg | sc-205332A | 5 mg | $825.00 |