Date published: 2025-12-8

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EDG-3 Activators

EDG-3 Activators, also known as Endothelial Differentiation GTPase 3 (EDG-3) activators, belong to a specific chemical class of compounds that are designed to modulate the activity of the EDG-3 receptor. The EDG-3 receptor, part of the sphingosine-1-phosphate (S1P) receptor family, plays a crucial role in various physiological processes within the human body, including cell migration, proliferation, and immune cell trafficking. EDG-3 activators are synthetic molecules carefully designed to interact with this receptor, either enhancing or inhibiting its signaling pathways. Structurally, EDG-3 activators typically comprise a diverse range of chemical scaffolds, with variations in their chemical makeup and functional groups. These compounds are engineered to specifically target the EDG-3 receptor, often through their three-dimensional shape and chemical properties, ensuring a high degree of selectivity. Once they bind to the receptor, they can modulate its activity, leading to downstream cellular responses. The precise mechanism of action can vary among different EDG-3 activators, some acting as agonists to stimulate receptor signaling, while others function as antagonists to block or reduce receptor activity. These compounds serve as valuable tools in scientific investigations to unravel the intricacies of S1P receptor signaling pathways and how they may influence fundamental cellular functions. As our understanding of the EDG-3 receptor and its activation mechanisms deepens, EDG-3 activators hold promise for future developments in diverse areas of research and applications.

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Items 1 to 10 of 13 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

D-erythro-Sphingosine-1-phosphate

26993-30-6sc-201383
sc-201383D
sc-201383A
sc-201383B
sc-201383C
1 mg
2 mg
5 mg
10 mg
25 mg
$162.00
$316.00
$559.00
$889.00
$1693.00
7
(1)

D-erythro-Sphingosine-1-phosphate, classified as an EDG-3, exhibits intriguing molecular behavior through its sphingolipid structure. This compound is known for its ability to interact with specific receptors, influencing cellular signaling pathways. Its unique stereochemistry contributes to selective binding, enhancing its role in lipid metabolism. The compound's hydrophilic and hydrophobic regions facilitate membrane interactions, impacting its reactivity and stability in biological systems.

FTY720 Phosphate

402615-91-2sc-205332
sc-205332A
1 mg
5 mg
$177.00
$809.00
6
(1)

FTY720 Phosphate, an EDG-3 compound, showcases distinctive molecular characteristics through its phosphorylated sphingosine backbone. This structure enables it to engage in specific hydrogen bonding and electrostatic interactions, influencing its solubility and reactivity. The compound's dynamic conformation allows for versatile interactions with lipid bilayers, affecting membrane fluidity and permeability. Its unique properties contribute to its role in modulating cellular responses and signaling cascades.

Forskolin

66575-29-9sc-3562
sc-3562A
sc-3562B
sc-3562C
sc-3562D
5 mg
50 mg
1 g
2 g
5 g
$76.00
$150.00
$725.00
$1385.00
$2050.00
73
(3)

Forskolin can activate adenylate cyclase, increasing cAMP levels, which may trigger a signaling cascade that leads to the upregulation of EDG-3 expression.

FTY720 (S)-Phosphate

402616-26-6sc-205331
sc-205331A
500 µg
1 mg
$113.00
$218.00
3
(1)

FTY720 (S)-Phosphate, classified as an EDG-3 compound, features a phosphoryl group that enhances its polar character, facilitating strong ionic interactions with surrounding molecules. This compound exhibits unique reactivity patterns, particularly in its ability to form stable complexes with metal ions, which can influence catalytic pathways. Its amphiphilic nature allows it to integrate into lipid environments, altering membrane dynamics and impacting molecular transport processes.

PMA

16561-29-8sc-3576
sc-3576A
sc-3576B
sc-3576C
sc-3576D
1 mg
5 mg
10 mg
25 mg
100 mg
$40.00
$129.00
$210.00
$490.00
$929.00
119
(6)

PMA activates protein kinase C, which could initiate transcriptional events increasing EDG-3 levels.

Lithium

7439-93-2sc-252954
50 g
$214.00
(0)

Lithium chloride can influence G-protein-coupled receptor signaling and may affect the expression of EDG-3 through modulation of signaling pathways.

Retinoic Acid, all trans

302-79-4sc-200898
sc-200898A
sc-200898B
sc-200898C
500 mg
5 g
10 g
100 g
$65.00
$319.00
$575.00
$998.00
28
(1)

Retinoic acid, through its receptors, can modulate gene expression and potentially upregulate EDG-3 by influencing cell differentiation pathways.

Cholecalciferol

67-97-0sc-205630
sc-205630A
sc-205630B
1 g
5 g
10 g
$70.00
$160.00
$290.00
2
(1)

Cholecalciferol (Vitamin D3), through its hormonal activity, may regulate the expression of various G-protein-coupled receptors, including EDG-3.

Eicosa-5Z,8Z,11Z,14Z,17Z-pentaenoic Acid (20:5, n-3)

10417-94-4sc-200766
sc-200766A
100 mg
1 g
$102.00
$423.00
(0)

EPA is known to modify inflammatory processes and may alter the expression of EDG-3 by modulating lipid signaling pathways.

Dexamethasone

50-02-2sc-29059
sc-29059B
sc-29059A
100 mg
1 g
5 g
$76.00
$82.00
$367.00
36
(1)

Dexamethasone, a glucocorticoid, may influence EDG-3 expression through the glucocorticoid response elements in the gene's promoter region.