FTY720 (S)-Phosphate (CAS 402616-26-6)

FTY720 (S)-Phosphate, more known as Fingolimod phosphate, is a sphingosine 1-phosphate (S1P) receptor modulator that plays a pivotal role in immunology and cellular biology research. Upon phosphorylation, FTY720 (S)-Phosphate acts by engaging with four of the five known types of S1P receptors. This interaction leads to the internalization and subsequent degradation of these receptors on the surface of lymphocytes, which significantly alters the lymphocytes′ ability to egress from lymph nodes. This mechanism effectively sequesters lymphocytes within lymph nodes, reducing their presence in circulating blood and affecting their participation in immune responses. In cellular studies, FTY720 (S)-Phosphate has been extensively utilized to dissect the intricate pathways of lymphocyte trafficking, offering insights into the dynamic regulation of the immune system. Moreover, its ability to cross the blood-brain barrier has made it useful in neuroscience research, particularly for studying neuroinflammation and the protective mechanisms of neurons against cytotoxicity. Through these applications, FTY720 (S)-Phosphate has contributed significantly to our understanding of both the immune system′s operations and the cellular mechanisms underlying neuroprotection, positioning it as a critical compound in the exploration of cellular responses and signaling pathways.