Date published: 2026-5-16

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EBV ZEBRA Inhibitors

EBV ZEBRA inhibitors, a class of compounds within the realm of medicinal chemistry, are characterized by their specific capacity to target and impede the activity of the Epstein-Barr Virus (EBV) ZEBRA protein. The EBV ZEBRA protein, also known as Zta or Z transactivator, plays a pivotal role in the life cycle of the Epstein-Barr Virus, a member of the herpesvirus family. This viral protein is crucial for the transition between latency and lytic replication phases in EBV's life cycle, making it an attractive target for drug development. EBV ZEBRA inhibitors are designed with the primary aim of obstructing the function of this protein, ultimately hampering the virus's ability to replicate and propagate within host cells. These inhibitors typically function by binding to specific regions of the EBV ZEBRA protein, thereby disrupting its interactions with essential cellular and viral components. By interfering with the ZEBRA protein's transactivation abilities, these compounds hinder the expression of viral genes required for lytic replication, effectively halting the virus's propagation.

Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Suberoylanilide Hydroxamic Acid

149647-78-9sc-220139
sc-220139A
100 mg
500 mg
$133.00
$275.00
37
(2)

Vorinostat, another histone deacetylase inhibitor, has been shown to affect the acetylation levels of histones, potentially impacting the transcription of viral genes including ZEBRA.

BAY 11-7082

19542-67-7sc-200615B
sc-200615
sc-200615A
5 mg
10 mg
50 mg
$62.00
$85.00
$356.00
155
(1)

Bay 11-7082 inhibits NF-κB activity, and since ZEBRA expression can be modulated by NF-κB, this compound could influence its expression levels.

Curcumin

458-37-7sc-200509
sc-200509A
sc-200509B
sc-200509C
sc-200509D
sc-200509F
sc-200509E
1 g
5 g
25 g
100 g
250 g
1 kg
2.5 kg
$37.00
$69.00
$109.00
$218.00
$239.00
$879.00
$1968.00
47
(1)

Curcumin has various biological activities, including anti-inflammatory and anti-viral effects, and it may influence ZEBRA expression through these mechanisms.

(±)-JQ1

1268524-69-1sc-472932
sc-472932A
5 mg
25 mg
$231.00
$863.00
1
(0)

JQ1 inhibits the BET family of bromodomains, affecting gene transcription. It could potentially influence the expression of ZEBRA by modulating the transcription machinery.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$123.00
$400.00
148
(1)

LY294002 is a PI3K inhibitor, and since the PI3K/Akt pathway can play a role in viral replication and expression, this compound might impact ZEBRA expression.

Quercetin

117-39-5sc-206089
sc-206089A
sc-206089E
sc-206089C
sc-206089D
sc-206089B
100 mg
500 mg
100 g
250 g
1 kg
25 g
$11.00
$17.00
$110.00
$250.00
$936.00
$50.00
33
(2)

Quercetin has antioxidant and anti-viral properties, and it may exert an inhibitory effect on ZEBRA expression through these activities.

SP600125

129-56-6sc-200635
sc-200635A
10 mg
50 mg
$40.00
$150.00
257
(3)

SP600125 is a JNK inhibitor, and since the JNK pathway can be involved in viral gene expression, this compound might affect the expression of ZEBRA.

Bortezomib

179324-69-7sc-217785
sc-217785A
2.5 mg
25 mg
$135.00
$1085.00
115
(2)

Bortezomib is a proteasome inhibitor, and it could potentially impact the stability and expression of ZEBRA protein by inhibiting its degradation.

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$63.00
$158.00
$326.00
233
(4)

Rapamycin inhibits mTOR, a key regulator of cell growth and protein synthesis, which might lead to a reduction in ZEBRA protein expression.

Resveratrol

501-36-0sc-200808
sc-200808A
sc-200808B
100 mg
500 mg
5 g
$80.00
$220.00
$460.00
64
(2)

Resveratrol has anti-viral and anti-inflammatory properties, and it might influence ZEBRA expression through these mechanisms.