Ear4 Activators
Ear4, a member of the eosinophil-associated ribonuclease A family, plays a vital role in orchestrating innate immune responses, with predicted functions that include ribonuclease activity, involvement in chemotaxis, and contributing to mucosal innate immune defenses. The ribonuclease activity associated with Ear4 implies its participation in the degradation of RNA molecules, a fundamental process essential for maintaining cellular homeostasis and regulating immune responses. Its predicted involvement in chemotaxis suggests a critical role in guiding immune cells to specific locations within the body, facilitating targeted immune responses, especially at mucosal surfaces. Moreover, the prediction that Ear4 is located in the lysosome underscores its role in the extracellular space, emphasizing its contribution to the host defense mechanisms in mucosal tissues.
The activation of Ear4 is a sophisticated process governed by a network of diverse cellular mechanisms and signaling pathways. Histone acetylation, influenced by specific chemicals, creates a permissive chromatin environment, facilitating the enhanced transcription of genes associated with innate immunity and chemotaxis, ultimately promoting Ear4 expression. Additionally, cAMP-mediated signaling cascades, modulated by various chemicals, indirectly contribute to Ear4 activation by influencing pathways related to chemotaxis and mucosal immune responses. Modulation of NF-κB signaling, a key regulatory pathway, plays a pivotal role in the fine-tuned control of genes associated with innate immunity, indirectly impacting Ear4 expression and contributing to the regulation of mucosal immune responses. Redox-sensitive pathways and the Wnt signaling pathway, influenced by distinct chemicals, further contribute to Ear4 activation, reflecting the complex regulatory landscape through which Ear4 fulfills its crucial role in innate immunity. In summary, Ear4's activation is a result of the intricate interplay of diverse cellular processes and signaling events, highlighting its significance as a molecular player in the complex framework of the innate immune system.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate, through histone acetylation, enhances transcription of genes involved in innate immunity. Ear4, associated with chemotaxis and mucosal responses, is indirectly activated as sodium butyrate alters chromatin structure, fostering a permissive environment for gene expression in relevant pathways. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, leading to elevated cAMP levels. Increased cAMP activates protein kinase A, influencing chemotaxis and innate immune responses. Indirectly, Ear4 expression is promoted through cAMP-mediated signaling cascades, modulating mucosal immune functions. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin modulates NF-κB signaling, impacting genes associated with innate immunity. Ear4 is indirectly activated through the inhibition of NF-κB, regulating mucosal immune responses. Quercetin's actions contribute to the promotion of Ear4 expression, affecting cellular processes related to chemotaxis. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid, a derivative of vitamin A, up-regulates Ear4 by activating retinoic acid receptors (RARs). RARs translocate to the nucleus, modulating gene expression. Ear4 is indirectly stimulated through RAR-mediated transcriptional events, impacting mucosal immune responses. | ||||||
Sodium Salicylate | 54-21-7 | sc-3520 sc-3520A sc-3520B sc-3520C | 1 g 25 g 500 g 1 kg | $10.00 $25.00 $80.00 $136.00 | 8 | |
Sodium salicylate inhibits NF-κB signaling, impacting innate immune response pathways. Ear4 is indirectly activated through the suppression of NF-κB, contributing to the regulation of mucosal immune responses. Sodium salicylate plays a role in promoting Ear4 expression, affecting cellular processes associated with chemotaxis. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic acid inhibits histone deacetylases, influencing chromatin structure and gene expression. Ear4, implicated in innate immune responses, is indirectly activated through valproic acid-mediated modifications in histone acetylation, impacting pathways related to mucosal immunity. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A inhibits histone deacetylases, promoting histone acetylation and influencing gene expression. Ear4, involved in chemotaxis and innate immune responses, is indirectly activated as trichostatin A modifies chromatin structure, fostering a conducive environment for gene transcription. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin modulates NF-κB signaling, impacting pathways associated with chemotaxis. Indirectly, Ear4 is activated through the regulation of NF-κB, influencing mucosal immune responses. Curcumin contributes to the promotion of Ear4 expression, playing a role in the modulation of innate immunity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates SIRT1, influencing histone deacetylation and gene expression. Ear4, involved in innate immune responses, is indirectly stimulated as resveratrol modifies chromatin structure, fostering a conducive environment for gene transcription in relevant pathways. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $33.00 $73.00 $265.00 $112.00 | 34 | |
N-Acetyl-L-cysteine acts as a precursor to glutathione, influencing redox homeostasis. Redox-sensitive pathways related to chemotaxis are indirectly affected, promoting Ear4 expression. The activation of Ear4 is mediated through redox-dependent signaling events, contributing to its involvement in innate immune responses. | ||||||