E2F-4 Activators

Common E2F-4 Activators include, but are not limited to Retinoic Acid, all trans CAS 302-79-4, 5-Azacytidine CAS 320-67-2, Etoposide (VP-16) CAS 33419-42-0, L-Mimosine CAS 500-44-7 and Roscovitine CAS 186692-46-6.

E2F-4 is a member of the E2F family of transcription factors, which play pivotal roles in the control of the cell cycle and action of tumor suppressor proteins. E2F-4, in particular, is involved in the regulation of late cell cycle genes in the G1 and S phases. E2F-4 Activators are a category of chemical compounds or molecules that influence the activity of E2F-4, a transcription factor belonging to the E2F family. E2F family members are key regulators of the cell cycle and play a critical role in coordinating processes such as cell growth, DNA replication, and cell division. Specifically, E2F-4 is known to modulate gene expression and cell cycle progression, and its activity is tightly regulated to ensure proper cell division and stop uncontrolled proliferation, which can lead to cancer.

Activation of E2F-4 typically involves its interaction with other proteins, known as pocket proteins like pRB (retinoblastoma protein). When E2F-4 forms a complex with pocket proteins, it becomes inactive, leading to the inhibition of genes required for cell cycle progression. E2F-4 Activators may function by disrupting these complexes, releasing E2F-4 to activate the transcription of specific target genes. These target genes are involved in various cellular processes, including DNA repair, apoptosis, and differentiation. Understanding how E2F-4 Activators modulate the activity of this transcription factor is crucial for elucidating the intricate mechanisms governing cell cycle control and the molecular events underlying conditions like cancer where cell cycle regulation is disrupted. This knowledge may offer insights into strategies for controlling cell proliferation and preventing abnormal cell growth.