E130203B14Rik Activators
Vstm4, a V-set and transmembrane domain-containing protein, intricately governs processes like endothelial cell migration, retina blood vessel maintenance, and vasculature development. Positioned in the extracellular region and plasma membrane, Vstm4's orthologous human counterpart suggests conserved functional significance. To activate Vstm4, a diverse set of chemicals emerges. Retinoic Acid, by engaging RAR/RXR receptors, enhances endothelial cell migration and vasculature development via Vstm4 up-regulation. Forskolin elevates cAMP levels, indirectly activating Vstm4 and contributing to its regulatory role in endothelial cell migration and retina blood vessel maintenance.
Epigallocatechin Gallate acts by modulating MAPK signaling, linking Vstm4 to enhanced endothelial cell migration. Lithium Chloride triggers Vstm4 through Wnt/β-catenin, illustrating a connection between this pathway and Vstm4 activation. Nicotinamide indirectly activates Vstm4 by influencing SIRT1, connecting cellular metabolism to Vstm4 regulation. SB431542 inhibits TGF-β/Smad, creating a permissive environment for Vstm4 up-regulation. 2-Deoxy-D-glucose alters metabolism, impacting Vstm4 expression indirectly. Prostaglandin E1 stimulates Vstm4 through the cAMP/PKA pathway, providing an indirect mechanism for Vstm4 activation. Wortmannin inhibits PI3K/Akt, impacting Vstm4 indirectly. Niclosamide, by destabilizing β-catenin, connects Wnt signaling to Vstm4 activation. Trichostatin A modulates HDAC, offering an epigenetic avenue for Vstm4 up-regulation. JNK Inhibitor VIII suppresses JNK signaling, indirectly activating Vstm4. These chemicals unveil the intricate web of pathways influencing Vstm4, providing valuable insights into potential regulatory mechanisms governing its function in crucial cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid, a derivative of vitamin A, up-regulates Vstm4 by influencing endothelial cell migration. It activates RAR/RXR receptors, promoting the transcription of genes involved in vasculature development, including Vstm4. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin Gallate promotes Vstm4 expression by modulating MAPK signaling. It enhances endothelial cell migration and contributes to vasculature development. The compound acts indirectly by inhibiting MAPK pathways, altering the cellular environment to favor Vstm4 up-regulation. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride triggers Vstm4 activation through the Wnt/β-catenin pathway. It inhibits GSK-3β, stabilizing β-catenin and initiating downstream signaling events. This leads to enhanced endothelial cell migration and contributes to vasculature development involving Vstm4. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $43.00 $65.00 $200.00 $815.00 | 6 | |
Nicotinamide indirectly activates Vstm4 by influencing SIRT1. SIRT1, when activated, promotes endothelial cell migration and vasculature development, implicating Vstm4. Nicotinamide enhances SIRT1 activity, creating a favorable cellular environment for Vstm4 up-regulation. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
SB431542 indirectly activates Vstm4 by inhibiting the TGF-β/Smad pathway. It hinders the suppressive effects of TGF-β, creating a permissive environment for endothelial cell migration and vasculature development. This indirectly influences Vstm4 expression by modulating the TGF-β pathway. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $65.00 $210.00 | 26 | |
2-Deoxy-D-glucose activates Vstm4 indirectly by inhibiting glycolysis. Glycolytic inhibition shifts cellular metabolism, impacting endothelial cell migration and vasculature development. Vstm4 expression benefits from altered metabolic conditions induced by 2-Deoxy-D-glucose. | ||||||
PGE1 (Prostaglandin E1) | 745-65-3 | sc-201223 sc-201223A | 1 mg 10 mg | $30.00 $142.00 | 16 | |
Prostaglandin E1 stimulates Vstm4 by activating the cAMP/PKA pathway. It enhances endothelial cell migration and vasculature development. The activation of cAMP/PKA signaling indirectly influences Vstm4 expression, illustrating a connection between prostaglandin E1 and Vstm4 up-regulation. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin triggers Vstm4 activation by inhibiting PI3K/Akt signaling. Inhibition of this pathway enhances endothelial cell migration and contributes to vasculature development. Wortmannin indirectly impacts Vstm4 by modulating the PI3K/Akt pathway, favoring the up-regulation of Vstm4. | ||||||
Niclosamide | 50-65-7 | sc-250564 sc-250564A sc-250564B sc-250564C sc-250564D sc-250564E | 100 mg 1 g 10 g 100 g 1 kg 5 kg | $37.00 $77.00 $184.00 $510.00 $1224.00 $5814.00 | 8 | |
Niclosamide activates Vstm4 by inhibiting Wnt signaling through destabilization of β-catenin. This modulation positively impacts endothelial cell migration and vasculature development, indirectly influencing Vstm4 expression. Niclosamide provides a mechanism for Wnt-dependent Vstm4 up-regulation. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A stimulates Vstm4 by inhibiting HDAC activity. This epigenetic regulation enhances endothelial cell migration and vasculature development, indirectly impacting Vstm4 expression through chromatin modification. Trichostatin A provides a mechanism for HDAC-dependent Vstm4 up-regulation. | ||||||