DUS2L Activators
Forskolin, an adenylate cyclase stimulator, exemplifies this class by increasing intracellular cAMP, which may enhance DUS2L function via phosphorylation events. Similarly, 8-Bromo-cAMP, a synthetic cAMP analog, and IBMX, a phosphodiesterase inhibitor, ensure that cAMP-mediated signaling is amplified or sustained, creating an environment conducive to the potential upregulation of DUS2L. Compounds like PMA activate protein kinase C, setting off a domino effect within cellular signaling networks that may impinge upon DUS2L's activity. Calcium ionophores, namely Ionomycin and A23187, by raising intracellular calcium levels, activate calcium-dependent signaling pathways that could intersect with the regulatory mechanisms of DUS2L, underlining the importance of calcium as a versatile second messenger in cellular signaling.
The inhibition of specific pathways can also indirectly modulate DUS2L. PD 98059 and LY294002 target MEK and PI3K pathways, respectively, potentially causing cellular adjustments that may impact DUS2L activity. This compensatory response illustrates the interconnectedness of cellular signaling networks. U73122 disrupts the generation of diacylglycerol and inositol trisphosphate by inhibiting phospholipase C, leading to alterations in calcium signaling that might affect DUS2L activity. Since the phosphorylation state of proteins is critical to their function, Okadaic Acid, by inhibiting protein phosphatases, could maintain proteins in a phosphorylated state, potentially affecting signaling cascades that involve DUS2L. Genistein, a tyrosine kinase inhibitor, and Staurosporine, a broad-spectrum kinase inhibitor, exemplify how modulating one signaling pathway can lead to broader changes within the cell's signaling architecture, potentially influencing DUS2L activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is a diterpene that directly activates adenylate cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP may enhance DUS2L activity by promoting phosphorylation events that can trigger a cascade of intracellular signaling, which may include the activation of the protein. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
8-Br-cAMP is a cell-permeable cAMP analog that can mimic the action of endogenous cAMP. It activates cAMP-dependent pathways, potentially upregulating DUS2L activity by influencing the secondary messenger systems within the cell that can lead to the activation of proteins involved in the signaling cascade. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, enzymes responsible for the breakdown of cAMP and cGMP. By preventing the degradation of these cyclic nucleotides, IBMX can raise their intracellular levels, fostering an environment that can increase DUS2L activity through enhanced signaling via these secondary messengers. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC) which is involved in a multitude of signaling pathways. PKC activation can lead to downstream effects that can activate DUS2L by promoting phosphorylation and changes in the intracellular signaling dynamics. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium levels. Elevated calcium can activate calmodulin and calcium-dependent kinases, which can subsequently increase the activity of many proteins, including possibly DUS2L, by altering phosphorylation states and other regulatory mechanisms within the cell. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is another calcium ionophore that can increase intracellular calcium concentration and potentially mimic the effects of ionomycin, leading to the activation of calcium-dependent signaling pathways. This can influence the activity of DUS2L through the modulation of the cellular signaling environment. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD 98059 is an inhibitor of MEK, which is upstream of the MAPK/ERK pathway. By inhibiting MEK, PD 98059 can lead to compensatory cellular responses, which may include the upregulation of alternative signaling pathways that can enhance the activity of DUS2L as the cell attempts to maintain homeostasis. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a potent inhibitor of PI3K, which can result in the modulation of downstream targets of the PI3K signaling pathway. This modulation can affect other signaling cascades within the cell that can lead to the activation of proteins such as DUS2L. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases PP1 and PP2A, leading to increased phosphorylation levels within the cell. This can affect multiple signaling pathways and potentially lead to increased DUS2L activity due to the higher state of protein phosphorylation that can influence signaling cascades. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that can alter signaling pathways by inhibiting phosphorylation events. This alteration can have broad effects on cellular signaling networks, potentially resulting in the modulation of DUS2L activity due to changes in the intracellular signaling landscape. | ||||||