DUB2 Inhibitors
DUB2 inhibitors are a class of chemical compounds specifically designed to target and inhibit the activity of DUB2, a member of the deubiquitinating enzyme (DUB) family that plays a crucial role in regulating the ubiquitin-proteasome system (UPS). DUB2 functions by removing ubiquitin chains from target proteins, which prevents their degradation by the proteasome. This activity is essential for modulating protein stability, recycling ubiquitin, and regulating diverse cellular processes, including signal transduction, transcription, and response to stress. By selectively deubiquitinating certain proteins, DUB2 influences their cellular fate, controlling whether they are degraded or preserved, thus impacting protein homeostasis. Inhibiting DUB2 disrupts this regulatory mechanism, leading to sustained ubiquitination and potentially altering the turnover, localization, or function of proteins that DUB2 normally acts upon.
Structurally, DUB2 inhibitors are typically designed to bind to the catalytic site of the enzyme, where they prevent its ability to cleave ubiquitin from substrates. These inhibitors may also target allosteric sites, inducing conformational changes that reduce DUB2's enzymatic activity. The use of DUB2 inhibitors helps researchers explore the specific biological functions of DUB2 and its role in cellular regulation. By inhibiting DUB2, scientists can observe the consequences of impaired deubiquitination, gaining insights into how this enzyme regulates key signaling pathways, stress responses, and protein quality control. Additionally, studying DUB2 inhibition allows for a broader understanding of the ubiquitin-proteasome system and how deubiquitination contributes to maintaining the delicate balance of protein synthesis and degradation in cells.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
WP1130 | 856243-80-6 | sc-364650 sc-364650A | 10 mg 50 mg | $490.00 $1484.00 | 1 | |
Thiol-dependent deubiquitinase inhibitor impacting Usp17lc. WP1130 disrupts the function of Usp17lc, preventing thiol-dependent deubiquitination. This inhibition hampers the enzymatic activity essential for protein deubiquitination within the endoplasmic reticulum membrane and potentially affects chordate embryonic development. | ||||||
P005091 | 882257-11-6 | sc-478535 | 10 mg | $155.00 | ||
Usp inhibitor affecting protein deubiquitination. P5091 inhibits Usp17lc, disrupting its thiol-dependent deubiquitinase activity. The inhibition impedes Usp17lc's role in deubiquitinating proteins, potentially altering cellular processes related to protein homeostasis within the endoplasmic reticulum membrane and influencing chordate embryonic development. | ||||||
NSC697923 | 343351-67-7 | sc-391107 sc-391107A | 1 mg 5 mg | $15.00 $52.00 | 3 | |
Deubiquitinase inhibitor influencing Usp17lc. NSC697923 disrupts thiol-dependent deubiquitination, inhibiting Usp17lc and preventing its enzymatic activity. This inhibition impacts protein deubiquitination processes within the endoplasmic reticulum membrane, potentially altering cellular homeostasis and influencing chordate embryonic development. | ||||||
IU1 | 314245-33-5 | sc-361215 sc-361215A sc-361215B | 10 mg 50 mg 100 mg | $138.00 $607.00 $866.00 | 2 | |
Ubiquitin-specific protease inhibitor affecting Usp17lc. IU1 inhibits Usp17lc, preventing its thiol-dependent deubiquitinase activity. This inhibition hampers the enzymatic processes crucial for protein deubiquitination within the endoplasmic reticulum membrane, potentially influencing cellular protein homeostasis and chordate embryonic development. | ||||||
Spautin-1 | 1262888-28-7 | sc-507306 | 10 mg | $168.00 | ||
Autophagy inhibitor affecting Usp17lc. Spautin-1 disrupts autophagy processes regulated by Usp17lc, indirectly influencing its thiol-dependent deubiquitination activity. This disruption potentially impacts protein deubiquitination within the endoplasmic reticulum membrane, altering cellular homeostasis and chordate embryonic development. | ||||||
UCH-L1 Inhibitor Inhibitor | 668467-91-2 | sc-356182 | 10 mg | $204.00 | 1 | |
Deubiquitinase inhibitor impacting Usp17lc. LDN-57444 disrupts the thiol-dependent deubiquitination activity of Usp17lc, inhibiting its enzymatic function. This inhibition influences protein deubiquitination processes within the endoplasmic reticulum membrane, potentially altering cellular homeostasis related to Usp17lc and chordate embryonic development. | ||||||
Glucocorticoid Receptor Modulator, CpdA | 14593-25-0 | sc-221677 | 25 mg | $150.00 | 2 | |
Deubiquitinase inhibitor affecting Usp17lc. CpdA disrupts the thiol-dependent deubiquitination activity of Usp17lc, inhibiting its enzymatic function. This inhibition potentially influences protein deubiquitination processes within the endoplasmic reticulum membrane, altering cellular homeostasis and chordate embryonic development. | ||||||
PR 619 | 2645-32-1 | sc-476324 sc-476324A sc-476324B | 1 mg 5 mg 25 mg | $77.00 $188.00 $431.00 | 1 | |
Broad-spectrum deubiquitinase inhibitor affecting Usp17lc. PR-619 disrupts the enzymatic activity of Usp17lc, preventing thiol-dependent deubiquitination. This inhibition potentially alters protein deubiquitination processes within the endoplasmic reticulum membrane, influencing cellular homeostasis and chordate embryonic development. | ||||||
Tyrphostin B42 | 133550-30-8 | sc-3556 | 5 mg | $26.00 | 4 | |
HB-EGF inhibitor impacting cellular processes downstream of Usp17lc. This compound indirectly influences Usp17lc by disrupting HB-EGF signaling, potentially altering protein deubiquitination processes within the endoplasmic reticulum membrane and cellular homeostasis, thus affecting chordate embryonic development. | ||||||