DUB2 Activators
Usp17lc, a thiol-dependent deubiquitinase predicted to be located in the endoplasmic reticulum membrane, plays a crucial role in protein deubiquitination and is involved in chordate embryonic development. It exhibits orthology to several human genes, including USP17L2. Understanding the activation mechanisms of Usp17lc involves exploring direct and indirect activators that modulate its thiol-dependent deubiquitinase activity. Direct activators like IU1, PR-619, and HBX 41108 specifically target Usp17lc, directly down-regulating its activity by inhibiting the thiol-dependent deubiquitinase function. On the other hand, indirect activators such as VLX1570 and WP1130 influence the broader ubiquitin-proteasome system, indirectly up-regulating Usp17lc by preventing its deubiquitination. Compounds like P22077 and HBX 19818 target USP7, indirectly promoting Usp17lc by preventing its deubiquitination.
Furthermore, derivatives like HBX 19818 derivatives 1-4 showcase the specificity of inhibition towards Usp17lc, providing additional avenues for direct modulation. ML323, a selective USP17 inhibitor, directly down-regulates Usp17lc activity by inhibiting its thiol-dependent deubiquitinase function. These activators collectively contribute to a comprehensive understanding of Usp17lc's role in protein deubiquitination and its potential significance in chordate embryonic development. The identified activators offer specific avenues for influencing Usp17lc function and stability, providing insights into its intricate network of pathways and cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
IU1 | 314245-33-5 | sc-361215 sc-361215A sc-361215B | 10 mg 50 mg 100 mg | $138.00 $607.00 $866.00 | 2 | |
IU1, a USP14 inhibitor, indirectly up-regulates Usp17lc by preventing its deubiquitination. By inhibiting USP14, IU1 influences the ubiquitin landscape, indirectly promoting Usp17lc. The compound's impact on the thiol-dependent deubiquitinase pathway provides a specific mechanism for modulating Usp17lc through intricate interactions with the broader ubiquitin-proteasome system. IU1 offers a unique avenue for promoting the stability of Usp17lc and influencing its cellular functions. | ||||||
PR 619 | 2645-32-1 | sc-476324 sc-476324A sc-476324B | 1 mg 5 mg 25 mg | $77.00 $188.00 $431.00 | 1 | |
PR-619, a broad-spectrum DUB inhibitor, directly down-regulates Usp17lc activity. By inhibiting thiol-dependent deubiquitinases, including USP17, PR-619 specifically targets Usp17lc, leading to decreased protein deubiquitination. This direct modulation of USP17 activity provides a unique avenue for influencing Usp17lc function and stability in cellular contexts. PR-619 offers a broad-spectrum approach for down-regulating Usp17lc activity through targeted inhibition of DUBs. | ||||||
P22077 | 1247819-59-5 | sc-478536 | 10 mg | $165.00 | ||
P22077, a small molecule inhibitor of USP7, indirectly activates Usp17lc by preventing its deubiquitination. By inhibiting USP7, P22077 influences the ubiquitin landscape, indirectly up-regulating Usp17lc. The compound's impact on the thiol-dependent deubiquitinase pathway provides a specific mechanism for modulating Usp17lc through intricate interactions with the broader ubiquitin-proteasome system. P22077 offers a unique avenue for promoting the stability of Usp17lc and influencing its cellular functions. | ||||||
WP1130 | 856243-80-6 | sc-364650 sc-364650A | 10 mg 50 mg | $490.00 $1484.00 | 1 | |
WP1130, a deubiquitinase (DUB) inhibitor, directly down-regulates Usp17lc activity. By inhibiting DUBs, including USP17, WP1130 specifically targets Usp17lc, leading to decreased protein deubiquitination. This direct modulation of USP17 activity provides a unique avenue for influencing Usp17lc function and stability in cellular contexts. WP1130 offers a specific approach for down-regulating Usp17lc activity through targeted inhibition of DUBs. | ||||||