Molecular structure of UCH-L1 Inhibitor, CAS Number: 668467-91-2
UCH-L1 Inhibitor Inhibitor (CAS 668467-91-2)
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Alternate Names:
LDN 57444; 5-Chloro-1-[(2,5-dichlorophenyl)methyl]-1H-indole-2,3-dione 3-(O-acetyloxime)
Application:
UCH-L1 Inhibitor is a potent, reversible, active site-directed UCH-L1 inhibitor
CAS Number:
668467-91-2
Purity:
≥98%
Molecular Weight:
397.64
Molecular Formula:
C17H11Cl3N2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
UCH-L1 Inhibitor is an isatin O-acyl oxime compound reported to act as a potent, reversible, competitive, and active site-directed inhibitor of UCH-L1 with greater selectivity over UCH-L3. For a UCH-L3 inhibitor, please see sc-204370.Additionally, UCH-L1 Inhibitor may act to increase proliferation of UCH-L1 expressing tumor cell line SH-SY5Y. Potentially useful for studying the roles of UCH-L1 in cancer, Parkinsons disease, and other neurological disorders. Permeability may vary from cell type to cell type.
UCH-L1 Inhibitor Inhibitor (CAS 668467-91-2) References
- Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. | Liu, Y., et al. 2003. Chem Biol. 10: 837-46. PMID: 14522054
- Characterisation of the Trichinella spiralis deubiquitinating enzyme, TsUCH37, an evolutionarily conserved proteasome interaction partner. | White, RR., et al. 2011. PLoS Negl Trop Dis. 5: e1340. PMID: 22013496
- Increased levels of UCHL1 are a compensatory response to disrupted ubiquitin homeostasis in spinal muscular atrophy and do not represent a viable therapeutic target. | Powis, RA., et al. 2014. Neuropathol Appl Neurobiol. 40: 873-87. PMID: 25041530
- Development of surface plasmon resonance imaging biosensors for detection of ubiquitin carboxyl-terminal hydrolase L1. | Sankiewicz, A., et al. 2015. Anal Biochem. 469: 4-11. PMID: 25312468
- Inhibition of UCH-L1 in oligodendroglial cells results in microtubule stabilization and prevents α-synuclein aggregate formation by activating the autophagic pathway: implications for multiple system atrophy. | Pukaß, K. and Richter-Landsberg, C. 2015. Front Cell Neurosci. 9: 163. PMID: 25999815
- Ubiquitin C-terminal hydrolase 1: A novel functional marker for liver myofibroblasts and a therapeutic target in chronic liver disease. | Wilson, CL., et al. 2015. J Hepatol. 63: 1421-8. PMID: 26264933
- Ubiquitin C-Terminal Hydrolase L1 regulates autophagy by inhibiting autophagosome formation through its deubiquitinating enzyme activity. | Yan, C., et al. 2018. Biochem Biophys Res Commun. 497: 726-733. PMID: 29462615
- UCH-L1 inhibition aggravates mossy fiber sprouting in the pentylenetetrazole kindling model. | Wen, Y., et al. 2018. Biochem Biophys Res Commun. 503: 2312-2318. PMID: 29964011
- Inhibition of UCH-L1 Deubiquitinating Activity with Two Forms of LDN-57444 Has Anti-Invasive Effects in Metastatic Carcinoma Cells. | Kobayashi, E., et al. 2019. Int J Mol Sci. 20: PMID: 31370144
- Inhibition of UCHL1 by LDN-57444 attenuates Ang II-Induced atrial fibrillation in mice. | Bi, HL., et al. 2020. Hypertens Res. 43: 168-177. PMID: 31700166
- The deubiquitinase UCHL1 regulates cardiac hypertrophy by stabilizing epidermal growth factor receptor. | Bi, HL., et al. 2020. Sci Adv. 6: eaax4826. PMID: 32494592
- Blockage of UCHL1 activity attenuates cardiac remodeling in spontaneously hypertensive rats. | Han, X., et al. 2020. Hypertens Res. 43: 1089-1098. PMID: 32541849
- UCH-L1 inhibitor LDN-57444 hampers mouse oocyte maturation by regulating oxidative stress and mitochondrial function and reducing ERK1/2 expression. | Yuan, P., et al. 2020. Biosci Rep. 40: PMID: 33030206
- UCHL1, a deubiquitinating enzyme, regulates lung endothelial cell permeability in vitro and in vivo. | Mitra, S., et al. 2021. Am J Physiol Lung Cell Mol Physiol. 320: L497-L507. PMID: 33438509
- UCHL1 protects against ischemic heart injury via activating HIF-1α signal pathway. | Geng, B., et al. 2022. Redox Biol. 52: 102295. PMID: 35339825
Inhibitor of:
20S Proteasome β7, 3BP2, C9orf82, CCP5, CCP6, DDI2, DUB1, DUB1A, DUB2, DUB2A, FAM63A, FBXW23, IBRDC1, MuRF2, OTUB1, OTUB2, OTUD1, OTUD3, OTUD5, OTUD6A, OTUD7B, PBF, PI31, PLIC-1, Ppil3, PPIL6, PSMD11, RFWD3, RMND5A, RNF182, RNF187, RNF215, Skeletrophin, UBE2H, Ubp-M, UBXN2B, UCH-L1, UCH-L3, UCH-L4, USP13, USP20, USP27X, USP30, USP32, USP35, USP37, USP38, USP4, USP40, USP44, USP47, USP48, USP5, USP52, USP6, and USP9Y.Activator of:
C19orf62_5430437P03Rik, C9orf142, EG368203, HAUSP, PARC, PSMD2, USP17L29, USP17L4, USP17L7, USP17L8, USP21, USP25, USP31, USP42, and USP54.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
UCH-L1 Inhibitor, 10 mg | sc-356182 | 10 mg | $200.00 |