DnaJC7 Activators
DnaJC7 Activators encompass a unique group of chemicals that can influence the activity of the DnaJC7 protein, a notable member of the DnaJ/Hsp40 family. This protein operates in tandem with Hsp70s, participating in crucial cellular procedures like protein folding, degradation, and shielding from aggregation. Given the intimate relationship DnaJC7 shares with Hsp70s, any modulation in Hsp70s can likely exert an effect on DnaJC7.
Among the chemicals identified, Geldanamycin, 17-AAG, and 17-DMAG serve as Hsp90 inhibitors. Their mode of action hinges on bolstering the expression of Hsp70s. Celastrol, on the other hand, can induce Hsp70 expression by acting on heat shock factor 1 (HSF1). An entirely different mechanism is seen with MG132, a proteasome inhibitor. By leading to protein aggregation, it can trigger an upregulated Hsp70 response, which can, in turn, impact DnaJC7. Then there's Ver-155008, a direct Hsp70 inhibitor. Its ability to tweak the balance of chaperone proteins can cast an influence over DnaJC7's behavior. Quercetin activates HSF1, subsequently driving an uptick in Hsp70 expression. MKT-077 zeroes in on the mitochondrial Hsp70, offering another pathway to modulate DnaJC7. JG-98, an allosteric inhibitor of Hsp70, impacts chaperone dynamics and thus holds relevance to DnaJC7. MAL3-101 offers a unique mechanism by suppressing the co-chaperone activity of Hsp70/Hsp40 pairs. Lastly, Methylene Blue and Triptolide can affect DnaJC7 by respectively intervening in the mitochondrial electron transport chain and curtailing Hsp70 transcription via HSF1 inhibition.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $39.00 $59.00 $104.00 $206.00 | 8 | |
Hsp90 inhibitor, which can increase the expression of Hsp70s. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $67.00 $156.00 | 16 | |
Hsp90 inhibitor, a derivative of Geldanamycin, can enhance the level of Hsp70s. | ||||||
17-DMAG, Hydrochloride Salt | 467214-21-7 | sc-396751 | 25 mg | $312.00 | ||
Another Hsp90 inhibitor, enhancing Hsp70 expression. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $158.00 | 6 | |
Induces Hsp70 expression due to its effect on heat shock factor 1 (HSF1). | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
Proteasome inhibitor that can lead to protein aggregation, potentially upregulating Hsp70 response. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Known to activate HSF1, leading to an increase in Hsp70 expression. | ||||||
MKT-077 | 147366-41-4 | sc-507514 | 5 mg | $175.00 | ||
Rhodacyanine dye that targets the mitochondrial Hsp70. | ||||||
JG-98 | 1456551-16-8 | sc-507517 | 5 mg | $224.00 | ||
Allosteric inhibitor of Hsp70, which can influence chaperone dynamics, potentially impacting DnaJC7. | ||||||
Methylene blue | 61-73-4 | sc-215381B sc-215381 sc-215381A | 25 g 100 g 500 g | $43.00 $104.00 $328.00 | 3 | |
Known to impact the mitochondrial electron transport chain, which might indirectly influence Hsp70s. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
It suppresses Hsp70 transcription by inhibiting the transactivation activity of HSF1. | ||||||