Molecular structure of MKT-077, CAS Number: 147366-41-4
MKT-077 (CAS 147366-41-4)
Alternate Names:
1-ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-pyridinium, monochloride; FJ-776
CAS Number:
147366-41-4
Molecular Weight:
432.0
Molecular Formula:
C21H22N3OS2•Cl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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MKT-077 (CAS 147366-41-4) References
- Pharmacokinetic analysis and antitumor efficacy of MKT-077, a novel antitumor agent. | Tatsuta, N., et al. 1999. Cancer Chemother Pharmacol. 43: 295-301. PMID: 10071980
- Activity of MKT 077, a rhodacyanine dye, against human tumor colony-forming units. | Petit, T., et al. 1999. Anticancer Drugs. 10: 309-15. PMID: 10327038
- Potentiation of the antiproliferative activity of MKT-077 by loperamide, diltiazem and tamoxifen. | Abdul, M. and Hoosein, N. 2003. Oncol Rep. 10: 2023-6. PMID: 14534737
- Uptake rate of cationic mitochondrial inhibitor MKT-077 determines cellular oxygen consumption change in carcinoma cells. | Chunta, JL., et al. 2012. PLoS One. 7: e37471. PMID: 22616013
- Selective Mitochondrial Uptake of MKT-077 Can Suppress Medullary Thyroid Carcinoma Cell Survival In Vitro and In Vivo. | Starenki, D. and Park, JI. 2015. Endocrinol Metab (Seoul). 30: 593-603. PMID: 26485469
- Analogs of the Heat Shock Protein 70 Inhibitor MKT-077 Suppress Medullary Thyroid Carcinoma Cells. | Hong, SK., et al. 2022. Int J Mol Sci. 23: PMID: 35162987
- Analyzing Interaction of Rhodacyanine Inhibitor 'MKT-077' with Plasmodium falciparum HSP70s. | Nainani, C., et al. 2024. Drug Metab Bioanal Lett.. PMID: 38231055
- MKT-077, a novel rhodacyanine dye in clinical trials, exhibits anticarcinoma activity in preclinical studies based on selective mitochondrial accumulation. | Koya, K., et al. 1996. Cancer Res. 56: 538-43. PMID: 8564968
- Selective damage to carcinoma mitochondria by the rhodacyanine MKT-077. | Modica-Napolitano, JS., et al. 1996. Cancer Res. 56: 544-50. PMID: 8564969
- MKT-077, localized lipophilic cation: antitumor activity against human tumor xenografts serially transplanted into nude mice. | Chiba, Y., et al. 1998. Anticancer Res. 18: 1047-52. PMID: 9615763
Inhibitor of:
CCT A, ERdj4, Heat shock protein family A (Hsp70), HSP 70, HSP 78, Ssa1, STCH, and TCP-1 β.Activator of:
DnaJB6, DnaJC7, and GRP 75.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MKT-077, 5 mg | sc-507514 | 5 mg | $175.00 |