DnaJC7 Antibody (82SS): sc-100716

DnaJC7 Antibody (82SS) is a mouse monoclonal IgG2a kappa light chain antibody that detects DnaJC7 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-DnaJC7 antibody (82SS) is available as the non-conjugated format. DnaJC7, also known as TPR2, TTC2, or DANJC7, is a member of the DnaJ family, which is one of the largest chaperone families and is characterized by diverse cellular localization and functions. DnaJ proteins, including DnaJC7, play a pivotal role in the heat shock protein 70 (HSP70) chaperone machinery, where DnaJC7 interacts with HSP70 to facilitate ATP hydrolysis, a critical step in protein folding and stabilization. DnaJC7 is particularly important due to involvement in the regulation of protein homeostasis, which is essential for cellular function and survival, especially under stress conditions. DnaJC7 is ubiquitously expressed, with highest levels found in the testis, liver, heart, and brain, indicating a vital role in various physiological processes. Cysteine-rich regions and zinc finger motifs in DnaJC7 contribute to peptide-binding capabilities, enhancing chaperone function and interaction with other proteins, thereby influencing pathways such as proteolysis, exocytosis, and endocytosis.

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DnaJC7 Antibody (82SS) References:

1. Analysis of the function of mycobacterial DnaJ proteins by overexpression and microarray profiling.  |  Stewart, GR., et al. 2004. Tuberculosis (Edinb). 84: 180-7. PMID: 15207487
2. The C-terminal (331-376) sequence of Escherichia coli DnaJ is essential for dimerization and chaperone activity: a small angle X-ray scattering study in solution.  |  Shi, YY., et al. 2005. J Biol Chem. 280: 22761-8. PMID: 15849180
3. DnaJA4 is a SREBP-regulated chaperone involved in the cholesterol biosynthesis pathway.  |  Robichon, C., et al. 2006. Biochim Biophys Acta. 1761: 1107-13. PMID: 16950652
4. The Hsp70 chaperone machines of Escherichia coli: a paradigm for the repartition of chaperone functions.  |  Genevaux, P., et al. 2007. Mol Microbiol. 66: 840-57. PMID: 17919282
5. DnaJ recruits DnaK to protein aggregates.  |  Acebrón, SP., et al. 2008. J Biol Chem. 283: 1381-1390. PMID: 17984091
6. Organization and expression of the dnaJ and dnaK genes of Escherichia coli K12.  |  Saito, H. and Uchida, H. 1978. Mol Gen Genet. 164: 1-8. PMID: 360036
7. Identification of the E. coli dnaJ gene product.  |  Georgopoulos, CP., et al. 1980. Mol Gen Genet. 178: 583-8. PMID: 6446654
8. Levels of DnaK and DnaJ provide tight control of heat shock gene expression and protein repair in Escherichia coli.  |  Tomoyasu, T., et al. 1998. Mol Microbiol. 30: 567-81. PMID: 9822822
9. Interaction of the Hsp70 molecular chaperone, DnaK, with its cochaperone DnaJ.  |  Suh, WC., et al. 1998. Proc Natl Acad Sci U S A. 95: 15223-8. PMID: 9860950

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-DnaJC7 Antibody (82SS) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-DnaJC7 Antibody (82SS) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

DnaJC7 Antibody (82SS) Specifications

Alternate Product Name: DnaJC7

Product Clone Name: 82SS

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-485

Epitope Target: DnaJC7

Epitope Species: human

Product Reactivity/Detection: DnaJC7

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for DnaJC7 Antibody (82SS): N/A