DnaJC5γ Inhibitors
The DnaJC5γ inhibitors primarily function by inhibiting key processes and pathways that DnaJC5γ is involved in. Cyclosporin A and FK506 are inhibitors of calcineurin, a protein that dephosphorylates synapsins. DnaJC5γ is involved in synaptic vesicle exocytosis, which is mediated by synapsins. Therefore, inhibition of calcineurin can indirectly decrease the functional activity of DnaJC5γ. Similarly, Guanabenz inhibits the stress-induced phosphatase PP1/GADD34 complex, which can impact the phosphorylation status of synapsins, indirectly leading to the decreased functional activity of DnaJC5γ. Leflunomide, an inhibitor of dihydroorotate dehydrogenase, indirectly affects DnaJC5γ by inhibiting nucleotide synthesis, which is required for synaptic vesicle exocytosis.
Bafilomycin A1 and Concanamycin A function by inhibiting the vacuolar type H+-ATPase (V-ATPase), a crucial component for the acidification of vesicles, an essential step for neurotransmitter loading and hence synaptic vesicle exocytosis. Inhibition of this process can indirectly decrease the functional activity of DnaJC5γ. Salubrinal, an inhibitor of eIF2α dephosphorylation, can affect protein synthesis, which indirectly impacts the functional activity of DnaJC5γ, as it is involved in synaptic vesicle exocytosis. Tunicamycin inhibits N-linked glycosylation, a post-translational modification that can indirectly affect the functional activity of DnaJC5γ, which assists in protein folding and maturation. Proteasome inhibitors like MG132 and Bortezomib can indirectly affect the functionality of DnaJC5γ, which might be involved in protein degradation pathways. Finally, 2-Deoxyglucose and 3-Bromopyruvate, inhibitors of glycolysis, can indirectly affect the functional activity of DnaJC5γ, which is part of protein homeostasis requiring energy.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
Cyclosporin A is an inhibitor of calcineurin, a protein that dephosphorylates synapsins. Since DnaJC5γ is involved in the regulation of synaptic vesicle exocytosis, which is mediated by synapsins, the inhibition of calcineurin by Cyclosporin A can indirectly lead to the decreased functional activity of DnaJC5γ. | ||||||
FK-506 | 104987-11-3 | sc-24649 sc-24649A | 5 mg 10 mg | $78.00 $151.00 | 9 | |
FK506 is another inhibitor of calcineurin. Just like Cyclosporin A, by inhibiting calcineurin, FK506 can indirectly decrease the functional activity of DnaJC5γ. | ||||||
Leflunomide | 75706-12-6 | sc-202209 sc-202209A | 10 mg 50 mg | $20.00 $83.00 | 5 | |
Leflunomide is an inhibitor of dihydroorotate dehydrogenase, an enzyme involved in pyrimidine synthesis. As DnaJC5γ is involved in synaptic vesicle exocytosis, which requires ATP (a type of nucleotide), inhibition of nucleotide synthesis can indirectly affect the functional activity of DnaJC5γ. | ||||||
Guanabenz HCl | 23113-43-1 | sc-507500 | 100 mg | $246.00 | ||
Guanabenz inhibits the stress-induced phosphatase PP1/GADD34 complex, which can impact the phosphorylation status of synapsins. Since DnaJC5γ is involved in the regulation of synaptic vesicle exocytosis, which is mediated by synapsins, the inhibition of stress-induced phosphatase by Guanabenz can indirectly lead to the decreased functional activity of DnaJC5γ. | ||||||
Salubrinal | 405060-95-9 | sc-202332 sc-202332A | 1 mg 5 mg | $34.00 $104.00 | 87 | |
Salubrinal is a selective inhibitor of eIF2α dephosphorylation. Because DnaJC5γ operates in the context of synaptic vesicle exocytosis, which relies on protein synthesis, inhibiting eIF2α dephosphorylation (which is crucial for protein synthesis) can indirectly affect the functional activity of DnaJC5γ. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $98.00 $255.00 $765.00 $1457.00 | 280 | |
Bafilomycin A1 is a specific inhibitor of the vacuolar type H+-ATPase (V-ATPase). V-ATPase is crucial for the acidification of vesicles, an essential step for neurotransmitter loading and hence synaptic vesicle exocytosis. Inhibiting this process can indirectly reduce the functional activity of DnaJC5γ. | ||||||
Concanamycin A | 80890-47-7 | sc-202111 sc-202111A sc-202111B sc-202111C | 50 µg 200 µg 1 mg 5 mg | $66.00 $167.00 $673.00 $2601.00 | 109 | |
Concanamycin A is another inhibitor of V-ATPase. By inhibiting V-ATPase, Concanamycin A can indirectly decrease the functional activity of DnaJC5γ. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Tunicamycin inhibits N-linked glycosylation, a post-translational modification. As DnaJC5γ assists in protein folding and maturation, the inhibition of glycosylation can indirectly affect the functional activity of DnaJC5γ. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG132 is a proteasome inhibitor. As DnaJC5γ might be involved in protein degradation pathways, inhibiting the proteasome can alter these pathways and indirectly affect the function of DnaJC5γ. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Bortezomib is another proteasome inhibitor. Given that DnaJC5γ can participate in protein degradation pathways, inhibiting the proteasome with Bortezomib can indirectly affect the functionality of DnaJC5γ. | ||||||