DHRS4L2 Inhibitors
DHRS4L2 inhibitors encompass a variety of chemical compounds that act through distinct biochemical mechanisms to diminish the functional activity of this enzyme. Some inhibitors target the enzyme's cofactor availability, for instance, by impacting the synthesis or regeneration of essential cofactors that DHRS4L2 relies on for its catalytic function, thereby indirectly reducing its activity. Others act by competitively inhibiting the enzyme, where the inhibitor molecules resemble the natural substrates of DHRS4L2 closely enough to compete for binding, thus preventing the enzyme from interacting with its true substrates. This competition can be due to either synthetic retinoids or endogenous retinoid analogs that mimic the structure of the retinoids DHRS4L2 is meant to reduce.
Further mechanisms of DHRS4L2 inhibition involve the modulation of metabolic processes that indirectly influence the enzyme's activity. Some compounds disrupt the metabolic balance of alcohols and aldehydes, which are related to the substrates and products of DHRS4L2, thereby affecting its function. Others may alter the enzyme's substrate availability by influencing the absorption and bioavailability of retinoids, which are key for DHRS4L2's action. Additionally, there are chemicals that can affect retinoid signaling and metabolism, potentially leading to a decrease in DHRS4L2's enzymatic activity through complex feedback and regulatory pathways that govern retinoid homeostasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
Targets and inhibits dihydrofolate reductase, leading to decreased production of tetrahydrofolate, a cofactor DHRS4L2 requires for the reduction of retinoids, thereby indirectly inhibiting DHRS4L2 activity. | ||||||
13-cis-Retinoic acid | 4759-48-2 | sc-205568 sc-205568A | 100 mg 250 mg | $74.00 $118.00 | 8 | |
A retinoid that competitively inhibits retinol dehydrogenases, potentially reducing DHRS4L2 activity by substrate competition. | ||||||
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Alters retinoid metabolism by modulating retinol dehydrogenase activity, which could indirectly decrease DHRS4L2 function by altering the substrate availability. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Inhibits aldehyde dehydrogenase, and by altering aldehyde metabolism, it could indirectly affect DHRS4L2 activity due to metabolic interplay. | ||||||
Fomepizole | 7554-65-6 | sc-252838 | 1 g | $74.00 | 1 | |
Inhibits alcohol dehydrogenase and could indirectly decrease DHRS4L2 activity by modulating the balance of alcohols and aldehydes, which are related to the substrates and products of DHRS4L2. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
A retinoid that could compete with the natural substrates of DHRS4L2, potentially inhibiting its enzymatic activity through substrate competition. | ||||||
Bisphenol A | 80-05-7 | sc-391751 sc-391751A | 100 mg 10 g | $300.00 $490.00 | 5 | |
Can disrupt endogenous steroid hormone synthesis, potentially affecting the retinoid metabolism and thereby indirectly influencing DHRS4L2 function. | ||||||
Omeprazole | 73590-58-6 | sc-202265 | 50 mg | $66.00 | 4 | |
Proton pump inhibitor which could alter gastric pH and consequently affect the absorption and bioavailability of retinoids, indirectly reducing DHRS4L2 activity. | ||||||
Acitretin | 55079-83-9 | sc-210754 | 25 mg | $148.00 | 1 | |
A synthetic retinoid that could inhibit DHRS4L2 by competing with its natural substrates for retinoid binding and reduction. | ||||||
4-Hydroxyphenylretinamide | 65646-68-6 | sc-200900 sc-200900A | 5 mg 25 mg | $104.00 $315.00 | ||
A synthetic retinoid that can modulate retinoid signaling and metabolism, potentially decreasing the functional activity of DHRS4L2 through substrate competition. | ||||||