DDX37 Activators
DDX37 activators belong to a specialized category of chemical agents that are designed to interact with the DDX37 protein, a member of the DEAD-box protein family. The DEAD-box proteins are so named because of the conserved motif Asp-Glu-Ala-Asp (DEAD) that they all possess. These proteins are a subgroup of helicases, which are enzymes that unwind nucleic acids, and they play a pivotal role in various aspects of RNA metabolism, including splicing, ribosome biogenesis, and the initiation of translation. DDX37, in particular, is a putative RNA helicase, and the activators targeting this protein are developed to modulate its activity. The regulation of helicase activity is crucial because it affects the dynamics of RNA structures and thus has a significant impact on the RNA-dependent processes within the cell.
The chemical composition of DDX37 activators is tailored to bind specifically to the DDX37 protein, affecting its conformation and, consequently, its function. The activators are designed to either enhance or modulate the helicase activity of DDX37, which, in turn, can influence the RNA processes that the helicase regulates. This modulation of activity can have cascading effects on the molecular pathways within the cell, altering the landscape of nucleic acid interactions and functions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $117.00 $344.00 | 3 | |
Augments cellular ATP levels, directly enhancing DDX37's ATP-dependent RNA unwinding activity. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Increases cellular cAMP levels, stimulating RNA metabolism pathways and potentially amplifying DDX37 activity. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
Activates AMPK pathway, which indirectly boosts RNA processing functions and may elevate DDX37 activity. | ||||||
D-(−)-Ribose | 50-69-1 | sc-221458 sc-221458A sc-221458B sc-221458C sc-221458D sc-221458E sc-221458F | 5 g 25 g 100 g 250 g 1 kg 5 kg 10 kg | $26.00 $58.00 $112.00 $235.00 $612.00 $1224.00 $2040.00 | 1 | |
Enhances RNA synthesis; increased RNA levels could lead to higher DDX37 activity for RNA processing. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Elevates cAMP levels, which can stimulate RNA metabolism and possibly demand more from DDX37. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Activates Nrf2 pathway, altering gene transcription, and indirectly upregulating DDX37 activity due to increased RNA production. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
Inhibits NF-κB activation, thus modifying gene transcription and increasing demand for DDX37's RNA processing activity. | ||||||
Daidzein | 486-66-8 | sc-24001 sc-24001A sc-24001B | 100 mg 500 mg 5 g | $28.00 $79.00 $165.00 | 32 | |
Alters various signaling pathways, potentially increasing DDX37 activity by amplifying RNA production. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Modifies gene expression, leading to an enhanced need for DDX37 in RNA processing. | ||||||
Dimethyl fumarate | 624-49-7 | sc-239774 | 25 g | $28.00 | 6 | |
Modulates Nrf2 pathway, affecting gene transcription and potentially enhancing DDX37's role in RNA processing. | ||||||