DDX31 Inhibitors

Probable ATP-dependent RNA helicase DDX31 plays an instrumental role in unwinding RNA secondary structures, facilitating several pivotal processes within the realm of RNA metabolism. Among these processes are RNA splicing, ribosome biogenesis, and RNA decay. Helicases like DDX31 function as ATP-dependent enzymes, deriving their energy from the hydrolysis of ATP to drive the unwinding of RNA duplexes. This unwinding ability is crucial because RNA duplexes can form between two RNA strands or within a single RNA strand, creating structural motifs that might need modification or resolution during various cellular activities. By unwinding these structures, DDX31 potentially regulates the proper functioning, stability, and utilization of RNA molecules within the cell.

DDX31 Inhibitors primarily includes compounds that could potentially interfere with the expression or function of DDX31. From the provided list, we observe inhibitors that act upon various molecular mechanisms, ranging from altering gene expression to directly or indirectly impacting RNA or DNA synthesis. For instance, compounds like 5-Azacytidine could modify the DNA methylation state, which in turn might repress the expression of DDX31. Others, like Trichostatin A or Valproic acid, affect histone modification, thereby altering the chromatin structure around the DDX31 gene and potentially influencing its expression. In contrast, agents like Actinomycin D, DRB, and α-amanitin directly target the transcription machinery, potentially leading to a decrease in DDX31 transcription. Understanding the broad spectrum of mechanisms through which these compounds operate gives insights into the intricate regulatory networks and checkpoints governing the expression and activity of RNA helicases like DDX31.