DDX19B Inhibitors
Chemical inhibitors of DDX19B target the protein's essential functions, such as ATP hydrolysis and RNA binding, which are critical for its helicase activity involved in nucleocytoplasmic transport of RNA. Novobiocin serves a similar function by binding to the ATPase domain of DDX19B, thereby impeding the necessary conformational changes required for its RNA helicase function. Aurintricarboxylic Acid inhibits DDX19B by obstructing the interaction between the protein and RNA, as it binds to the nucleic acid binding sites of DDX19B, which prevents the protein from performing its RNA-unwinding function. Interference with nucleic acid structures is another strategy employed by inhibitors such as Ethidium Bromide and Berberine; these compounds intercalate with nucleic acids, altering their structure and thus inhibiting DDX19B's ability to bind or unwind its substrate.
Additional chemicals, like Amsacrine and Mitoxantrone, disrupt the function of DDX19B by similar means. By inserting themselves into DNA, they create a distorted nucleic acid structure that DDX19B cannot effectively engage with, thereby hindering its helicase action. Actinomycin D binds to DNA and impedes DNA-dependent RNA synthesis, leading to inhibition of DDX19B by steric hindrance, preventing the protein from interacting with its RNA substrate. Suramin and Heparin inhibit DDX19B through a different mechanism; they bind to the protein and obstruct its interaction with RNA substrates, which is essential for its helicase activity. Oxaliplatin forms DNA adducts and crosslinks that are not easily unwound by DDX19B, leading to the inhibition of the protein's helicase activity. Lastly, Daunorubicin, through its intercalation into DNA, prevents the unwinding action of DDX19B, thus inhibiting the protein's role in the nucleocytoplasmic transport of RNA.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Novobiocin | 303-81-1 | sc-362034 sc-362034A | 5 mg 25 mg | $128.00 $380.00 | ||
Novobiocin binds to and inhibits the ATPase activity which is essential for the helicase activity of DDX19B. This results in the inhibition of the conformational changes required for DDX19B to function in nucleocytoplasmic transport of RNA. | ||||||
Aurintricarboxylic Acid | 4431-00-9 | sc-3525 sc-3525A sc-3525B sc-3525C | 100 mg 1 g 5 g 10 g | $20.00 $32.00 $48.00 $94.00 | 13 | |
It inhibits the interaction between DDX19B and RNA by binding to the nucleic acid binding sites on DDX19B, preventing the protein from performing its RNA-unwinding function. | ||||||
Ethidium bromide | 1239-45-8 | sc-203735 sc-203735A sc-203735B sc-203735C | 1 g 5 g 25 g 100 g | $48.00 $150.00 $588.00 $2086.00 | 12 | |
By intercalating with nucleic acids, Ethidium Bromide alters the structure of RNA or DNA, inhibiting DDX19B’s ability to bind or unwind its substrate due to the structural changes in the nucleic acids. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Similar to Ethidium Bromide, Berberine intercalates into DNA, distorting the nucleic acid structures and thus hindering DDX19B from effectively binding and unwinding RNA, which is necessary for its helicase activity. | ||||||
Amsacrine hydrochloride | 54301-15-4 | sc-214540 | 10 mg | $232.00 | ||
Amsacrine interferes with the nucleic acid substrates of DDX19B by intercalating into DNA and preventing the unwinding action of DDX19B through the distortion of nucleic acid structures. | ||||||
Mitoxantrone | 65271-80-9 | sc-207888 | 100 mg | $285.00 | 8 | |
Mitoxantrone intercalates into DNA and disrupts DNA synthesis and DNA repair, which in turn can inhibit the unwinding of nucleic acids necessary for DDX19B's activity. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
This compound binds to DNA and disrupts DNA-dependent RNA synthesis by steric hindrance, which can inhibit the RNA helicase activity of DDX19B as it prevents the necessary interaction of the protein with its RNA substrate. | ||||||
Suramin sodium | 129-46-4 | sc-507209 sc-507209F sc-507209A sc-507209B sc-507209C sc-507209D sc-507209E | 50 mg 100 mg 250 mg 1 g 10 g 25 g 50 g | $152.00 $214.00 $728.00 $2601.00 $10965.00 $21838.00 $41096.00 | 5 | |
Suramin binds to proteins and nucleotides, and its bulky structure can inhibit the ATPase and helicase activity of DDX19B by preventing the necessary interactions with ATP or RNA. | ||||||
Heparin | 9005-49-6 | sc-507344 | 25 mg | $119.00 | 1 | |
While primarily an anticoagulant, Heparin also binds to proteins interacting with nucleic acids. It can inhibit DDX19B by binding to the protein and sterically hindering its interaction with RNA substrates, thus inhibiting its helicase activity. | ||||||
Oxaliplatin | 61825-94-3 | sc-202270 sc-202270A | 5 mg 25 mg | $112.00 $394.00 | 8 | |
Forms DNA adducts and crosslinks within DNA which are not efficiently unwound by DDX19B, leading to inhibition of its helicase activity. | ||||||