DCC1 Activators
DCC1, known as DNA replication and sister chromatid cohesion 1, is a protein associated with the maintenance of genomic stability, a critical aspect of cellular function and integrity. It is encoded by the gene DCC1, which is located on chromosome 17 in humans.The protein DCC1 plays a pivotal role in the establishment of sister chromatid cohesion during DNA replication. Sister chromatid cohesion is essential for accurate chromosome segregation during cell division, as it ensures that each daughter cell receives an identical set of chromosomes. DCC1 is a subunit of the cohesion establishment complex, which also includes proteins such as CTF8 and CTF18. This complex is thought to act in parallel with the cohesin complex, which directly mediates the cohesion of sister chromatids.
DCC1's function is intricately linked to the process of DNA replication, as the establishment of cohesion is closely coordinated with the replication fork. The cohesion complex, including DCC1, is responsible for the recruitment of cohesin to newly replicated DNA and for regulating its function during the S phase of the cell cycle. By participating in this process, DCC1 helps to safeguard the correct alignment and separation of chromosomes, preventing aneuploidy and genomic instability, which are hallmarks of cancer and other genetic disorders.In addition to its role in sister chromatid cohesion, DCC1 is also involved in the DNA damage response. It is part of a mechanism that detects and repairs replication-associated DNA damage, further contributing to the maintenance of genomic stability.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Aphidicolin | 38966-21-1 | sc-201535 sc-201535A sc-201535B | 1 mg 5 mg 25 mg | $84.00 $306.00 $1104.00 | 30 | |
Aphidicolin is a tetracyclic diterpene antibiotic that specifically inhibits DNA polymerase α, indirectly affecting DCC1 by altering the dynamics of DNA replication. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Camptothecin, a topoisomerase I inhibitor, induces DNA damage that can modulate the activity of proteins involved in DNA replication and repair, potentially influencing DCC1 function. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide, a topoisomerase II inhibitor, can indirectly affect DCC1 by causing DNA damage and altering the replication process, which DCC1 is a part of. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin forms DNA adducts and induces DNA damage, potentially impacting DCC1 activity as the protein responds to replication stress. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $66.00 $101.00 $143.00 | 85 | |
Mitomycin C is an alkylating agent that causes DNA cross-linking, indirectly influencing DCC1's role in DNA replication and chromosomal cohesion. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Hydroxyurea inhibits ribonucleotide reductase, leading to decreased deoxyribonucleotide levels and affecting DNA replication, thereby potentially influencing DCC1 activity. | ||||||
2′-Deoxy-2′,2′-difluorocytidine | 95058-81-4 | sc-275523 sc-275523A | 1 g 5 g | $56.00 $128.00 | ||
Gemcitabine is a nucleoside analog that inhibits DNA synthesis, indirectly affecting DCC1 by altering the DNA replication landscape. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
5-Fluorouracil is a thymidylate synthase inhibitor that leads to thymidine depletion, indirectly affecting DNA replication and potentially DCC1 activity. | ||||||
Bleomycin | 11056-06-7 | sc-507293 | 5 mg | $275.00 | 5 | |
Bleomycin causes DNA breaks, potentially influencing DCC1 activity in the context of DNA replication and repair. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $210.00 $305.00 $495.00 | 10 | |
Olaparib, a PARP inhibitor, can influence DNA repair mechanisms, indirectly affecting proteins like DCC1 involved in DNA replication and chromosomal maintenance. | ||||||