DCC1 Inhibitors

DCC1, also known as DNA replication and sister chromatid cohesion 1, is a protein that plays a vital role in the maintenance of genomic stability during cell division. It is a component of the alternative replication factor C (RFC) complex, which is involved in the processes of DNA replication and sister chromatid cohesion.The RFC complexes are loaders of the proliferating cell nuclear antigen (PCNA) onto DNA. PCNA is a critical factor acting as a sliding clamp that encircles DNA, providing a platform for the assembly of factors involved in DNA synthesis, repair, and cell cycle control. DCC1, as part of the alternative RFC complex, specifically participates in the loading of PCNA onto DNA at sites of replication and repair.

During DNA replication, DCC1 contributes to the establishment of sister chromatid cohesion, which is essential for ensuring that each daughter cell receives an identical and complete set of chromosomes during cell division. This cohesion is mediated by a protein complex called cohesin, and the alternative RFC complex, including DCC1, is important for the loading of cohesin onto chromatin.DCC1 is also involved in the response to DNA damage. It contributes to the stability and localization of the alternative RFC complex to sites of stalled replication forks, which can occur due to the presence of DNA lesions. This activity is crucial for the process of DNA repair and for the prevention of replication stress, which can lead to genomic instability.Given its fundamental role in DNA replication and maintenance of genomic integrity, DCC1 is of great interest in cancer research.