DANGER Inhibitors
Chemical inhibitors of DANGER act through various mechanisms to disrupt the protein's function, primarily by interfering with calcium signaling pathways essential for its activity. 2-Aminoethoxydiphenyl borate (2-APB) inhibits the inositol 1,4,5-trisphosphate receptor (IP3R), leading to a reduction in calcium release from the endoplasmic reticulum, which is a critical step for DANGER's function. Xestospongin C also targets IP3R, preventing the calcium release required for DANGER to carry out its cellular roles. Thapsigargin, by inhibiting the SERCA pump, effectively depletes intracellular calcium stores, indirectly inhibiting DANGER's calcium-dependent signaling. SKF-96365 disrupts receptor-mediated calcium entry while TMB-8 impedes intracellular calcium release, both reducing the calcium balance necessary for DANGER's activity. Through these actions, these chemicals functionally inhibit DANGER by curtailing the protein's ability to participate in calcium-mediated cellular processes.
Additional chemicals operate by blocking specific channels or enzymes that indirectly affect DANGER's activity. Mibefradil and Nifedipine are calcium channel blockers that limit calcium influx, which is likely necessary for DANGER's signaling functions. U73122 inhibits phospholipase C, reducing the production of IP3 and, consequently, decreasing DANGER's involvement in calcium signaling. ML-9 targets myosin light-chain kinase, affecting downstream calcium signaling that DANGER may rely on. BAPTA serves as a calcium chelator, sequestering free intracellular calcium and thus inhibiting calcium-dependent pathways in which DANGER is implicated. Ryanodine modulates ryanodine receptors, and Dantrolene directly inhibits these receptors, both diminishing the calcium signaling critical for DANGER's activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $27.00 $52.00 | 37 | |
2-Aminoethoxydiphenyl borate (2-APB) is known to inhibit the inositol 1,4,5-trisphosphate receptor (IP3R), which is a pathway DANGER is involved in. By inhibiting IP3R, 2-APB can decrease calcium release from the endoplasmic reticulum, thus functionally inhibiting DANGER's activity related to calcium signaling. | ||||||
Xestospongin C | 88903-69-9 | sc-201505 | 50 µg | $500.00 | 14 | |
Xestospongin C is an inhibitor of the IP3R. By inhibiting this receptor, it can prevent the calcium release that DANGER may utilize for its function, leading to a decrease in DANGER-mediated cellular processes. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor that leads to depletion of intracellular calcium stores. By depleting calcium, it indirectly inhibits DANGER's role in calcium-dependent signaling pathways. | ||||||
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $101.00 $155.00 $389.00 $643.00 | 2 | |
SKF-96365 inhibits receptor-mediated calcium entry, which is crucial for maintaining the calcium balance that DANGER's activity may rely on. This inhibition can reduce DANGER's ability to influence calcium-dependent processes. | ||||||
TMB-8 • HCl | 53464-72-5 | sc-3522 sc-3522A | 10 mg 50 mg | $42.00 $126.00 | 10 | |
TMB-8 acts as an inhibitor of intracellular calcium release. As DANGER is associated with calcium signaling, TMB-8's inhibition of calcium release can functionally inhibit DANGER by reducing calcium-dependent signaling events. | ||||||
Mibefradil dihydrochloride | 116666-63-8 | sc-204083 sc-204083A | 10 mg 50 mg | $209.00 $848.00 | 4 | |
Mibefradil is a T-type calcium channel blocker. By blocking these channels, it can reduce calcium influx that may be necessary for DANGER's calcium-mediated signaling, leading to functional inhibition of DANGER. | ||||||
ML-9 | 105637-50-1 | sc-200519 sc-200519A sc-200519B sc-200519C | 10 mg 50 mg 100 mg 250 mg | $110.00 $440.00 $660.00 $1200.00 | 2 | |
ML-9 is a kinase inhibitor that can inhibit myosin light-chain kinase (MLCK). Since MLCK is involved in calcium signaling pathways, ML-9 can indirectly affect DANGER's function by disrupting downstream calcium-dependent mechanisms. | ||||||
BAPTA, Free Acid | 85233-19-8 | sc-201508 sc-201508A | 100 mg 500 mg | $67.00 $262.00 | 10 | |
BAPTA is a calcium chelator that can bind free intracellular calcium, thereby reducing calcium levels and inhibiting calcium-dependent pathways in which DANGER is involved, leading to its functional inhibition. | ||||||
Ryanodine | 15662-33-6 | sc-201523 sc-201523A | 1 mg 5 mg | $219.00 $765.00 | 19 | |
Ryanodine modulates ryanodine receptors which are involved in calcium release from the sarcoplasmic/endoplasmic reticulum. By modulating these receptors, it can diminish the calcium signaling that is essential for DANGER's activity. | ||||||
Dantrolene | 7261-97-4 | sc-500165 | 25 mg | $350.00 | 7 | |
Dantrolene inhibits ryanodine receptors, which are crucial for calcium release from the endoplasmic reticulum. Inhibition of these receptors can lead to decreased calcium signaling and therefore functional inhibition of DANGER. | ||||||