Molecular structure of Mibefradil dihydrochloride, CAS Number: 116666-63-8
Mibefradil dihydrochloride (CAS 116666-63-8)
See product citations (4)
Alternate Names:
Ro 40-5967; Posicor
Application:
Mibefradil dihydrochloride is selectively blocks Ca2+ entry into cells by inhibiting T-type Ca2+ channels
CAS Number:
116666-63-8
Purity:
≥98%
Molecular Weight:
568.55
Molecular Formula:
C29H38FN3O3•2HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Mibefradil dihydrochloride is a nondihydropyridine antagonist and calcium channel protein inhibitor which selectively blocks Ca2+ entry into cells by inhibiting T-type (low-voltage activated) Ca2+ channels. In addition, it has been reported that mibefradil dihydrochloride can partially inhibit L-type (high-voltage activated) Ca2+ channels. Studies show that when this compound is combined with nisoldipine (sc-212396), an L-type Ca2+ antagonist, all calcium channels are completely blocked. Furthermore, in vitro studies indicate that mibefradil dihydrochloride protect CA1 neurons from delayed death after global ischemia in rats.
Mibefradil dihydrochloride (CAS 116666-63-8) References
- A post-marketing observational study to assess the safety of mibefradil in the community in England. | Riley, J., et al. 2002. Int J Clin Pharmacol Ther. 40: 241-8. PMID: 12078937
- Reversal of experimental neuropathic pain by T-type calcium channel blockers. | Dogrul, A., et al. 2003. Pain. 105: 159-68. PMID: 14499432
- The sources and sequestration of Ca(2+) contributing to neuroeffector Ca(2+) transients in the mouse vas deferens. | Brain, KL., et al. 2003. J Physiol. 553: 627-35. PMID: 14500773
- Metabolism of calcium antagonist Ro 40-5967: a case history of the use of diode-array u.v. spectroscopy and thermospray-mass spectrometry in the elucidation of a complex metabolic pathway. | Wiltshire, HR., et al. 1992. Xenobiotica. 22: 837-57. PMID: 1455903
- Induction of apoptosis by the calcium antagonist mibefradil correlates with depolarization of the membrane potential and decreased integrin expression in human lens epithelial cells. | Nebe, B., et al. 2004. Graefes Arch Clin Exp Ophthalmol. 242: 597-604. PMID: 15069564
- Hemodynamic profile of Ro 40-5967 in conscious rats: comparison with diltiazem, verapamil, and amlodipine. | Véniant, M., et al. 1991. J Cardiovasc Pharmacol. 18 Suppl 10: S55-8. PMID: 1725005
- In vitro pharmacologic profile of Ro 40-5967, a novel Ca2+ channel blocker with potent vasodilator but weak inotropic action. | Osterrieder, W. and Holck, M. 1989. J Cardiovasc Pharmacol. 13: 754-9. PMID: 2472524
- Activation of transient receptor potential ankyrin 1 induces CGRP release from spinal cord synaptosomes. | Quallo, T., et al. 2015. Pharmacol Res Perspect. 3: e00191. PMID: 27022465
- ZD7288 and mibefradil inhibit the myogenic heartbeat in Daphnia magna indicating its dependency on HCN and T-type calcium ion channels. | Pirtle, TJ., et al. 2018. Comp Biochem Physiol A Mol Integr Physiol. 222: 36-42. PMID: 29684576
- The Ca(++)-channel blocker Ro 40-5967 blocks differently T-type and L-type Ca++ channels. | Mehrke, G., et al. 1994. J Pharmacol Exp Ther. 271: 1483-8. PMID: 7996461
- Selective inhibition of T-type Ca2+ channels by Ro 40-5967. | Mishra, SK. and Hermsmeyer, K. 1994. Circ Res. 75: 144-8. PMID: 8013072
- Nonlinear pharmacokinetics of mibefradil in the dog. | Skerjanec, A., et al. 1996. J Pharm Sci. 85: 189-92. PMID: 8683447
- Pharmacologic and pharmacokinetic profile of mibefradil, a T- and L-type calcium channel antagonist. | Abernethy, DR. 1997. Am J Cardiol. 80: 4C-11C. PMID: 9286848
- Mibefradil, a T-channel-selective calcium antagonist: clinical trials in hypertension. | Oparil, S. 1998. Am J Hypertens. 11: 88S-94S. PMID: 9607372
- Inhibition of myogenic tone by mibefradil in rat cerebral arteries. | Lam, E., et al. 1998. Eur J Pharmacol. 358: 165-8. PMID: 9808266
Inhibitor of:
C11orf20, CaBP1, Cacna2d3, Calcium Channel Protein, CaT1, CatSperδ, CatSperγ, CIB2, CNG-2, DANGER, EF-HC1, EG631584, IP3R-III, L-type Ca++ CP β1, L-type Ca++ CP γ5, Mas 7, Mitsugumin23, OCT, Olfr1458, Olfr655, OR1S1, R-type calcium channel α1E, Raftlin, SHISA4, T-type Ca++ CP α1G, T-type calcium channel α1G, T-type calcium channel α1H, T-type calcium channel α1I, TMEM120B, TMEM86B, TPCN2, Triadin, Troponin T, Tuftelin, UNC-80, V3R 8, VILIP-2, and Vmn1r115.Activator of:
IZUMO2, NCKX6, P/Q-type calcium channel α1A, T-type calcium channel α1G, and T-type calcium channel α1H.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Mibefradil dihydrochloride, 10 mg | sc-204083 | 10 mg | $213.00 | |||
Mibefradil dihydrochloride, 50 mg | sc-204083A | 50 mg | $865.00 |