DANGER Antibody (H-7): sc-514861
- DANGER Antibody (H-7) is a mouse monoclonal IgG1 κ DANGER antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 419-434 near the C-terminus of DANGER of mouse origin
- DANGER Antibody (H-7) is recommended for detection of DANGER of mouse origin by WB, IP, IF and ELISA
- Anti-DANGER Antibody (H-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for DANGER Antibody (H-7) for WB applications. This reagent is now offered in a bundle with DANGER Antibody (H-7) (see ordering information below).
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SEE ALSO...
DANGER Antibody (H-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects DANGER protein of mouse origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-DANGER antibody (H-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. DANGER protein, also known as inositol 1,4,5-triphosphate receptor-interacting protein (ITPRIP) or KIAA1754, is a crucial 547 amino acid protein that plays a significant role in calcium signaling by interacting with inositol 1,4,5-triphosphate receptors (IP3Rs). IP3Rs are essential for mediating calcium release from the endoplasmic reticulum, which is vital for various cellular processes, including muscle contraction, neurotransmitter release, and cell proliferation. DANGER enhances the Ca(2+)-regulated inhibition of IP3R-mediated calcium release, thereby fine-tuning calcium signaling pathways. DANGER gene is located on human chromosome 10, which spans nearly 135 million base pairs and contains approximately 1,200 genes, including those involved in critical biological functions such as immune response and cell adhesion. Understanding DANGER′s role in calcium signaling is important for elucidating potential implications in various physiological and pathological processes, including neurodegenerative diseases and cancer.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
DANGER Antibody (H-7) References:
- Report of the third international workshop on human chromosome 10 mapping and sequencing 1999. | Deloukas, P., et al. 2000. Cytogenet Cell Genet. 90: 1-12. PMID: 11060438
- Friend virus induced murine erythroleukaemia: the p53 locus. | Johnson, P. and Benchimol, S. 1992. Cancer Surv. 12: 137-51. PMID: 1638545
- DANGER, a novel regulatory protein of inositol 1,4,5-trisphosphate-receptor activity. | van Rossum, DB., et al. 2006. J Biol Chem. 281: 37111-6. PMID: 16990268
- Sequence and functional characterization of a third inositol trisphosphate receptor subtype, IP3R-3, expressed in pancreatic islets, kidney, gastrointestinal tract, and other tissues. | Blondel, O., et al. 1993. J Biol Chem. 268: 11356-63. PMID: 8388391
- Calcineurin associated with the inositol 1,4,5-trisphosphate receptor-FKBP12 complex modulates Ca2+ flux. | Cameron, AM., et al. 1995. Cell. 83: 463-72. PMID: 8521476
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DANGER Antibody (H-7) | sc-514861 | 200 µg/ml | $316.00 | |||
DANGER Antibody (H-7): m-IgG Fc BP-HRP Bundle | sc-526395 | 200 µg Ab; 10 µg BP | $354.00 | |||
DANGER Antibody (H-7) AC | sc-514861 AC | 500 µg/ml, 25% agarose | $416.00 | |||
DANGER Antibody (H-7) HRP | sc-514861 HRP | 200 µg/ml | $316.00 | |||
DANGER Antibody (H-7) FITC | sc-514861 FITC | 200 µg/ml | $330.00 | |||
DANGER Antibody (H-7) PE | sc-514861 PE | 200 µg/ml | $343.00 | |||
DANGER Antibody (H-7) Alexa Fluor® 488 | sc-514861 AF488 | 200 µg/ml | $357.00 | |||
DANGER Antibody (H-7) Alexa Fluor® 546 | sc-514861 AF546 | 200 µg/ml | $357.00 | |||
DANGER Antibody (H-7) Alexa Fluor® 594 | sc-514861 AF594 | 200 µg/ml | $357.00 | |||
DANGER Antibody (H-7) Alexa Fluor® 647 | sc-514861 AF647 | 200 µg/ml | $357.00 | |||
DANGER Antibody (H-7) Alexa Fluor® 680 | sc-514861 AF680 | 200 µg/ml | $357.00 | |||
DANGER Antibody (H-7) Alexa Fluor® 790 | sc-514861 AF790 | 200 µg/ml | $357.00 | |||
DANGER (H-7) Neutralizing Peptide | sc-514861 P | 100 µg/0.5 ml | $68.00 |