DAF-4 Inhibitors
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
This small molecule inhibits TGF-β type I receptor ALK5, which is involved in the Smad2/3 pathway. Since DAF-4 is a TGF-β receptor, inhibition of ALK5 by SB-431542 prevents phosphorylation of Smad2/3, leading to reduced signal transduction and inhibition of DAF-4-related TGF-β signaling. | ||||||
LY 364947 | 396129-53-6 | sc-203122 sc-203122A | 5 mg 10 mg | $107.00 $156.00 | 4 | |
LY364947 is a selective inhibitor of the TGF-β type I receptor ALK5. By inhibiting ALK5 kinase activity, LY364947 suppresses the phosphorylation of Smad proteins, which are downstream of DAF-4, thus inhibiting the TGF-β/Smad signaling pathway and subsequently DAF-4 signaling. | ||||||
A 83-01 | 909910-43-6 | sc-203791 sc-203791A | 10 mg 50 mg | $202.00 $811.00 | 16 | |
A-83-01 selectively inhibits ALK5, ALK4, and ALK7, which are TGF-β type I receptors. DAF-4 signaling relies on similar pathways, and thus A-83-01 inhibits DAF-4 by hindering the phosphorylation of Smad proteins and the propagation of the TGF-β signaling pathway. | ||||||
TGF-β RI Kinase Inhibitor V | 627536-09-8 | sc-203294 | 2 mg | $88.00 | 3 | |
SD-208 is a TGF-β receptor I (ALK5) kinase inhibitor. By blocking the kinase activity of ALK5, SD-208 disrupts the Smad-dependent signaling pathway, which is necessary for DAF-4 function, thus effectively inhibiting DAF-4 activity. | ||||||
EW-7197 | 1352608-82-2 | sc-507465 | 5 mg | $345.00 | ||
EW-7197 is a potent inhibitor of ALK5 kinase activity. It prevents the phosphorylation and activation of Smad2/3 proteins in the downstream TGF-β signaling pathway, which are essential for DAF-4 signal transduction, leading to DAF-4 inhibition. | ||||||
LY2157299 | 700874-72-2 | sc-391123 sc-391123A | 5 mg 10 mg | $213.00 $359.00 | 3 | |
LY2157299, also known as Galunisertib, selectively inhibits ALK5, thereby blocking TGF-β signaling. This results in decreased Smad2/3 phosphorylation and inhibits DAF-4 signaling processes that depend on this pathway. | ||||||
ALK5 Inhibitor II | 446859-33-2 | sc-221234 sc-221234A sc-221234B sc-221234C sc-221234D sc-221234E sc-221234F | 1 mg 5 mg 10 mg 50 mg 100 mg 500 mg 1 g | $77.00 $153.00 $219.00 $663.00 $1248.00 $4382.00 $7850.00 | 8 | |
RepSox is an ALK5 inhibitor that impedes the TGF-β/Smad signaling pathway. By doing so, it leads to the inhibition of the phosphorylation of Smad2/3, which are downstream of DAF-4, thus inhibiting DAF-4 activity. | ||||||
GW788388 | 452342-67-5 | sc-363544 sc-363544A | 5 mg 25 mg | $95.00 $384.00 | ||
GW788388 is a potent and selective inhibitor of both ALK5 and ALK4, which are involved in TGF-β signaling. Inhibition of these receptors' kinase activity prevents activation of the Smad2/3 pathway, thereby inhibiting DAF-4 signaling. | ||||||
IN-1130 | 868612-83-3 | sc-507462 | 25 mg | $435.00 | ||
IN-1130 is an ALK5 inhibitor that disrupts TGF-β-mediated phosphorylation of Smad proteins. Since Smad proteins are downstream of DAF-4, inhibiting their activation with IN-1130 effectively inhibits DAF-4 activity. | ||||||
SB-505124 | 694433-59-5 | sc-362794 sc-362794A | 10 mg 50 mg | $327.00 $1377.00 | 2 | |
SB-505124 selectively inhibits ALK4, ALK5, and ALK7, thereby impeding the phosphorylation and activation of Smad2/3 proteins that are crucial for TGF-β signaling. This inhibition affects the signal transduction of DAF-4, leading to its inhibition. | ||||||